… a promising combinatorial therapy with MEK inhibitors to treat KRAS mutant lung cancers. …
to understand the mechanisms of MEK inhibitor resistance in KRAS mutant lung cancers and …

… inhibitor JQ1 suppressed interferon-stimulated gene (ISG) expression and in combination
with MEK inhibitors … the limited response to MEK inhibitors in KRAS-mutant colorectal cancer, …

… Using synthetic lethal shRNA screening in KRAS mutant cancer models, BCL-XL was
found … In this study of KRAS-mutant lung cancer models, combining MEK inhibition with …

… In this study, we showed that HSP90 inhibitor could be a good candidate with MEK inhibitor
as a combination therapy of NSCLC patients harboring KRAS mutation. Lung cancer can be …

… In support of this, a recent study using KRAS mutation-driven mouse models demonstrated
higher efficacy of the MEK inhibitor selumetinib in KRAS G12C tumors compared with …

… , wherein tumor inhibition function and … KRAS-MEK inhibitors in combination with radiotherapy
can enhance antitumor immunity, providing new therapeutic strategies for KRAS-mutated …

… I inhibitor that blocks OXPHOS, significantly impeded tumor growth and prolonged mouse
survival. Overall, our findings reveal that MEK inhibitor … MEK inhibitors resistance in KRAS-…

… strategy for promoting apoptosis of KRAS mutant cancer cells that harbor … inhibitors synergize
with MEK inhibitors by upregulating BIM and PUMA and induce apoptosis in KRAS mutant …

… , MEK inhibitors were reported to induce RAF-MEK complexes, thus leading to MEK inhibition
resistance in KRAS mutant … This CRAF-mediated MEK reactivation can be impaired in new-…

… in BRAF-mutated melanoma, MEK inhibitors appeared to be … of MEK inhibitor to identify
genes that are synthetically lethal with MEK inhibition in CRC models harboring KRAS mutations. …