… Taken together, we speculate that the pathway reactivation in KRAS-mutant cell lines may
be broadly and dominantly mediated by SHP2 though they may exhibit differential sensitivity …

… These studies overall suggest the reactivation of MAPK signaling and/or mutant KRAS-independent
activation of the PI3K pathway as common modalities to bypass KRAS G12C …

… in RAS mutant models but only additive in BRAF mutant models … We discovered that pathway
reactivation in RAS mutant models … in KRAS mutant setting demonstrates clear pathway …

… The KRAS mutations favor the active form with inhibition of GTPAse activity. KRAS mutations
are … mechanism to reactivate RAS signaling if one of the two KRAS pathway is blocked. If …

… reactivation of ERK-dependent signaling to bypass KRAS … identified adaptive RAS pathway
feedback reactivation as a … G12C mutation and conversion to a different KRAS mutation …

… reactivated despite dabrafenib treatment, we reevaluated the possibility of other activating
somatic mutations within the MAPK pathway … 8,9 activating KRAS mutation (KRAS Q61H ), but …

… Unlike most PTPs, numerous studies indicate that SHP2 functions in the activation of
intracellular signalling pathways, particularly the KRAS/ERK pathway 34 . SHP2 is a common …

… KRAS mutations occur in a quarter of all of human cancers, … that block KRAS G12C , the
majority of KRAS oncoproteins … (MAPK) pathway as targets to treat KRAS-mutant cancers by …

… alone is not capable to suppress MAPK pathway in RAS-mutated cancers and that co-targeting
of upstream receptors might be a way to avoid pathway reactivation [26]. Two seminal …

… K-RAS mutation or K-RASwt overexpression results from the activation of the EGFR-independent
PI3K-Akt pathway… to the K-RAS-mediated and ERK2-dependent reactivation of Akt and …