… Interestingly, only those cells bearing KRAS mutations that maintain intrinsic GTPase …
Furthermore, gene expression signatures may help stratify patients for optimal RTK inhibitors [107]. …

… of the RTK-PI3K-AKT pathway in the KRAS/BRAF mutant CRC … of BRAF/KRAS mutant CRC
cells mainly by inhibiting AKT … of six KRAS mutant CRC cell lines and two BRAF mutant CRC …

… MEK inhibition in KRAS mutated colorectal cancer models, MEK inhibitor alone has shown
limited antitumor activity in KRAS … colorectal cancer cell lines have higher basal level of RTK …

… We aim to summarize the tumor heterogeneity of KRAS mutant lung cancers and its … inhibitors
alone or in combination with RTK inhibitors have failed to prove effective in KRAS mutant …

… McFall et al. report that other KRAS mutants are highly effective … of upstream RTK activity.
In contrast, they report that the … MAPK inhibition increased the dependency of KRAS mutant …

… However, the exact mechanism by which RTK signaling leads to RAS-MAPK … of KRAS G12C
inhibitors is unclear. One proposed mechanism is that increased RTK signaling shifts KRAS …

… kinase inhibitors act on the tyrosine kinase domain of RTK, … Mutations in RAS family of genes
(K-RAS, N-RAS, H-RAS) … High frequency of KRAS mutations are found in pancreatic, large …

… G12C mutant xenografts [28] STK11 co-mutations in KRAS mutant NSCLC have been …
Furthermore, this study identified no single RTK that was critical for all KRAS G12C models …

… from RTK signalling are needed, in which case KRAS-mutant tumours will still benefit from
RTK inhibition. Moreover, to define colorectal cancer as KRAS mutant versus KRAS wild-type …

… with the highest rate of KRAS mutations are pancreatic (88%)… therapies specifically inhibiting
mutated forms of KRAS or its … (RTK); in particular, KRAS G12C - and KRAS-mutant NSCLC …