… not identified common hits for KRAS mutant cancer cells that … combination with mutation-specific
and pan-KRAS inhibitors. … that promotes RTK–KRAS signaling in KRAS-driven cancers …

… We and others previously reported that acquired KRAS mutations … We reasoned that KRAS
inhibitors could have clinical … on RTK signaling across KRAS G12C -mutant tumors can be …

… inhibition as an unexpected vulnerability of KRAS-mutant … kinase kinase (MEK) inhibition in
KRAS-mutant lung and colon … as a readout of RTK activation in a panel of KRAS-mutant lung, …

… of KRAS mutations in human cancers and the lack of effective treatments for patients ranks
KRAS … for decades to identify small molecule inhibitors of oncogenic KRAS proteins, but little …

… of KRAS inhibitors, successful therapies for KRAS mutation-induced cancers, including the
direct inhibition of the activity of KRAS and inhibition of downstream KRAS signaling, via the …

… On-treatment feedback reactivation of the RAS-MAPK pathway, as a result of synthesis
and GTP-loading of new KRASG12C and/or RTK-driven activation of wild-type RAS, (KRAS, …

… KRAS G12C inhibitors … KRAS G12C covalent inhibitor GDC-6036 resulted in significant
regressions at doses well below those required for single agent activity in a KRAS G12C-mutant …

… KRAS mutant cancer, MAPK and PI3K pathway inhibitors have not demonstrated significant
clinical activity in patients with KRAS mutant … the feedback inhibition of RTK signaling [42]. In …

… KRAS mutations detection in the Italian real-word scenario, summarises the biological basis
of KRAS inhibition … Recent preclinical data identified RTK-mediated feedback reactivation of …

… /MEK inhibition is not only restricted to the KRAS mutant but is … As an integrator of RTK–RAS
signaling downstream of almost … only in RTK-driven tumors but also in KRAS-mutant tumors. …