Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
… To date, the brain tissue penetrance of intranasal oxytocinoxytocin intranasally and
intravenously to rhesus macaques and measure, with mass spectrometry, concentrations of labeled (…

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

MR Lee, KB Scheidweiler, XX Diao, F Akhlaghi… - Molecular …, 2018 - nature.com
… To address these questions, we developed a sensitive and specific quantitative mass
spectrometry assay that distinguishes labeled (d5-deuterated) from endogenous (d0) OT. We …

The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta)

SM Freeman, K Inoue, AL Smith, MM Goodman… - …, 2014 - Elsevier
… In marmosets, the authors labeled an area of OXTR expression in the basal forebrain as
the diagonal band of Broca (DB), but in marmoset brain tissue, the DB is very near to the NBM, …

Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)

SWC Chang, JW Barter, RB Ebitz… - Proceedings of the …, 2012 - National Acad Sciences
… with marked deficits in sensitivity to what happens to others, including impairments in
understanding and responding to social cues (22, 25, 26). Variations in a common oxytocin-…

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

ME Modi, F Connor-Stroud, R Landgraf… - …, 2014 - Elsevier
… Effect of AE, IN and IV OT on central and peripheral oxytocin (OT) levels. AE-OT administration
resulted in significant accumulation of OT in the lumbar CSF of rhesus monkeys, however …

Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology

SWC Chang, ML Platt - Brain research, 2014 - Elsevier
… strength of prosociality, rhesus macaques are outstanding models for … marked by social
deficits. Due to their remarkably similar anatomy and physiology to humans, rhesus macaques

Oxytocin‐and arginine vasopressin‐containing fibers in the cortex of humans, chimpanzees, and rhesus macaques

CN Rogers, AP Ross, SP Sahu… - American journal of …, 2018 - Wiley Online Library
… series of sections was labeled for OT, and an adjacent 1:12 series of sections labeled for AVP.
In … of both sexes in chimpanzees and rhesus macaques, our human brain tissue was from …

Intranasal oxytocin selectively modulates the behavior of rhesus monkeys in an expression matching task

J Taubert, M Flessert, N Liu, LG Ungerleider - Scientific Reports, 2019 - nature.com
Diagram illustrating the ratio of training/maintenance trials compared to test trials across the
identity task sessions. (E) Diagram … primate behavior, specifically in rhesus macaques, to our …

Oxytocin enhances attention to the eye region in rhesus monkeys

O Dal Monte, PL Noble, VD Costa… - Frontiers in …, 2014 - frontiersin.org
… Four male adult rhesus monkeys (Macaca … a rhesus monkey colony room with tactile, auditory,
and visual contact with one another. The colony rooms accommodate 24 rhesus monkeys, …

… innervation of vasopressin‐and oxytocin‐containing neurons in the hypothalamic paraventricular nucleus of the macaque monkey: quantitative analysis using double …

SD Ginsberg, PR Hof, WG Young… - Journal of …, 1994 - Wiley Online Library
… in order to assess the somatodendritic labeling of the immunohistochemical preparation. …
the PVH of 4 cynomolgus monkeys and 6 in the PVH of 2 rhesus monkeys) and 11 oxytocin-…