Heartworm disease, caused by Dirofilaria immitis, can be lethal in dogs and cats. It is transmitted
by mosquitoes, and occurs in many parts of the world. Prevention relies on macrocyclic …

… heartworm disease caused by Dirofilaria immitis in domestic dogs and cats relies on a single
drug class, the macrocyclic lactones (… that demonstrated resistance in D.immitis, along with …

… Dirofilaria immitis infection can be prevented by macrocyclic lactone (ML) prophylaxis
once a month (Bowman and Atkins, 2009). The minimal approved dose rate for prophylaxis in …

… lactone (ML) endectocides are used as chemoprophylaxis for heartworm infection (Dirofilaria
immitis… Claims of loss of efficacy (LOE) of ML heartworm preventives have become common …

… Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) …
If proven, and not controlled in the early stages, the emergence of ML drug resistance …

… primary strategy for heartworm control. Recent evidence has confirmed that ML-resistant
Dirofilaria immitis isolates have evolved. Comparison of genomes of ML-resistant isolates show …

… was insensitive to very high doses of macrocyclic lactones and was characterized by a high
… -resistant heartworm infection and suggest that a simple assay for the existence of resistant …

… Prevention of infection with canine heartworm (Dirofilaria immitis) is based on the
compliant administration of macrocyclic lactone (ML) drugs. Resistance to ML drugs is well …

… lactone (ML) drug class are widely used as preventives against the canine heartworm (Dirofilaria
immitis… in which dogs develop mature heartworm infection despite the administration of …

… lactones-resistant Dirofilaria immitis case in Europe. … lactone resistance in Dirofilaria
immitis: failure of heartworm preventives and investigation of genetic markers for resistance …