… lactone resistance in trichostrongyloid nematodes of ruminants and has been suggested to
be a marker for macrocyclic lactone resistance … heartworm resistance to macrocyclic lactones …

… cats, chemoprophylaxis with macrocyclic lactone (ML) preventives for heartworm disease is
… LOE) of heartworm preventives have been reported in the US More recently, ML-resistant D. …

… of genetic heterogeneity in the dog heartworm would have important implications for the
possible development of macrocyclic lactone resistance in D. immitis. Genetic variability was …

… Dirofilaria immitis infection is one of the most severe parasitic diseases in dogs. Prevention is
achieved by the administration of drugs containing macrocyclic lactones (… Dirofilaria immitis …

… with macrocyclic lactone (ML) anthelmintics has been the primary strategy for canine
heartworm (Dirofilaria immitis) control in both the USA and Australia. ML-resistant D. …

… -11) correlated with loss of efficacy of macrocyclic lactone anthelmintics, suggesting that
PGPs may be involved in macrocyclic lactone resistance in D. immitis. We have identified the full …

… In the present study, we selected a challenge based on a well-known resistant heartworm
isolate (JYD-34). The efficacy results of MBO against JYD-34 obtained in the present study (…

Dirofilaria immitis is a parasitic nematode and causes dirofilariosis, a potentially fatal … lactone
(ML) regimens. Recent evidence has confirmed the development of ML-resistant isolates in …

… lactone anthelmintics are the only class of drug currently used to prevent heartworm disease…
Their extremely high potency in vivo is not mirrored by their activity against Dirofilaria immitis …

… lactone (ML) resistance in Dirofilaria immitis, the parasitic nematode which causes heartworm
… The area is an ideal propagation region for heartworm infection and possibly for the …