… receptor for hepatitis C virus (HCV), because it has been shown to bind ‘bona fide’ HCV …
membrane four times forming two extracellular loops: a small (SEL) and a large one (LEL). …

… flexibility is exploited by HCV at cell entry, with the … virus-receptor complex to transit into the
fusogenic state. Our study provides insights into the influential role of hCD81 LEL on the HCV …

… To understand which tetraspanin backbone domains caused the observed deficiency in
HCV receptor function, we determined the sequence divergence of all tested chimeras from …

… between HCV E2 and the large extracellular loop (LEL) of the cellular receptor CD81 (CD81-…
, which allows for the extension of an internal loop consisting of residues 520–539. Docking …

… a likely receptor for the binding of hepatitis C virus (HCV) to hepatocytes and therefore a
possible target for novel anti-HCV drugs. The two published X-ray structures of the HCV binding …

… SR-BI is a Mr 82 000 glycoprotein with a large extracellular loop anchored to the plasma
membrane at both the N-termini and C-termini by transmembrane domains with short …

… domains, short intracellular domains and two extracellular loops called the small extracellular
loop (SEL) and the large extracellular loop (LEL). The LEL contains characteristic motifs, …

… receptors for HCV remains controversial. Lack of an efficient cell-culture system for the
replication of HCV … of molecules involved in the entry of HCV into cells. The traditional method of …

… cell entry, CD81 teraspanin, which contains a small extracellular loop, a large extracellular
loop (LEL), four transmembrane domains and intracellular N- and C-terminal domains, plays …

… In this report, immobilized HCV envelope proteins and cell surface receptor CD81LEL will
be referred to as “ligand” and “analyte,” respectively. SPR and molecular mass on the sensor …