The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
… first realistic experimental strategy for validation of drug targets for the treatment of latent TB.
… model for testing the ability of candidate drugs to eradicate latent TB. But given the time, cost …
… model for testing the ability of candidate drugs to eradicate latent TB. But given the time, cost …
Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies
… Treatment of latent tuberculosis (LTBI) is a vital component of tuberculosis (TB) elimination
but … Treatment of LTBI with isoniazid targets actively replicating bacilli but not non-replicating …
but … Treatment of LTBI with isoniazid targets actively replicating bacilli but not non-replicating …
A multi-pronged computational pipeline for prioritizing drug target strategies for latent tuberculosis
… strategies for targeting latent tuberculosis, new candidate drug targets as well as important
lead clues for drug … was to identify potential drug targets for latent TB. Transcriptome data was …
lead clues for drug … was to identify potential drug targets for latent TB. Transcriptome data was …
Novel drug target strategies against Mycobacterium tuberculosis
DJ Murphy, JR Brown - Current Opinion in Microbiology, 2008 - Elsevier
… Since currently used antibiotics target DNA replication, transcription, translation, or aspects
… a dormant or non-replicative state and successfully evade any immune response. Latent TB …
… a dormant or non-replicative state and successfully evade any immune response. Latent TB …
Latent tuberculosis infection: Opportunities and challenges
CBE Chee, R Reves, Y Zhang, R Belknap - Respirology, 2018 - Wiley Online Library
… and treating latent tuberculosis (TB) infection (LTBI) is … strategy to accelerate the decline in
global TB and achieve … Whether a single drug, or a combination of drugs targeting growing …
global TB and achieve … Whether a single drug, or a combination of drugs targeting growing …
The ongoing challenge of latent tuberculosis
H Esmail, CE Barry 3rd, DB Young… - … Transactions of the …, 2014 - royalsocietypublishing.org
… by 2050 is a bold one and the development of the post-2015 TB strategy and targets
provides an opportunity to identify the critical gaps in our knowledge and to focus the scientific …
provides an opportunity to identify the critical gaps in our knowledge and to focus the scientific …
Tuberculosis elimination and the challenge of latent tuberculosis
A Matteelli, G Sulis, S Capone, L D'Ambrosio… - La Presse Médicale, 2017 - Elsevier
… Policies for the programmatic management of latent TB should consider the risk of
progression of latent TB infection into active TB disease and those factors that determine it. For …
progression of latent TB infection into active TB disease and those factors that determine it. For …
Differential diagnosis of latent tuberculosis infection and active tuberculosis: a key to a successful tuberculosis control strategy
W Gong, X Wu - Frontiers in microbiology, 2021 - frontiersin.org
… , tuberculosis (TB) is still the leading cause of death from a single infectious agent worldwide.
Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and …
Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and …
[HTML][HTML] The spectrum of latent tuberculosis: rethinking the goals of prophylaxis
… strategies for the development and application of drugs to … of several anti-tubercular drug
targets including isoniazid (and … been used to study potential drug targets in subsystems of the …
targets including isoniazid (and … been used to study potential drug targets in subsystems of the …
Tuberculosis drug targets
… dormant TB bacteria is thought to be the cause for the lengthy TB chemotherapy, since the
current TB drugs … therapeutic strategies targeting the persistent or dormant organisms. Natural …
current TB drugs … therapeutic strategies targeting the persistent or dormant organisms. Natural …
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