‘Rational use of high‐flow therapy in infants with bronchiolitis. What do the latest trials tell us?’
A Paediatric Research in Emergency Departments International Collaborative perspective …

… high flow nasal cannula (HHHFNC), is a relatively new non-invasive ventilation therapy that
… Higher flow rates up to 50 L/min have been used in studies including older children and …

… Clinical studies in general populations of critically ill patients have found that high-flow therapy
during … High-flow therapy after extubation has demonstrated clinical benefits in specific …

… clinical studies or meta-analyses. PICO stands for four different potential components of a
clinical … trials to identify clinical heterogeneity amongst trials. If two or more randomized …

… gained increasing acceptance in the treatment of respiratory conditions. Studies of NHF in
this … In conclusion, NHF is a new respiratory support modality into which little clinical research …

… and early observational studies proposed using high-flow oxygen therapy through a nasal
cannula … Thus, this current trial was conducted to assess the effect of high-flow oxygen therapy …

… This research is governed by the CNIL ‘Reference Method for processing personal data
for clinical studies’ (MR-001, amended). AP-HP, the sponsor, has signed a declaration of …

… definition, that is an inescapable complication of the conduct of clinical trials. … studies to
optimize the administration of oxygen and its more widespread use as an acute attack treatment …

… trials assessing the clinical utility of NHF in adult patients after cardiac surgery—all in patients
who have respiratory failure before commencing the therapy. … usual care oxygen therapy. …

… most cost effective therapy. So far, there have not been well designed clinical trials published,
… of McConnochie20 for bronchiolitis, based on age and clinical manifestations. Most of the …