Perineuronal nets gain prominence for their role in learning, memory, and plasticity

HH Shen - Proceedings of the National Academy of …, 2018 - National Acad Sciences
… already exhibited these memories, removing the nets interfered with … memories over time
(14). Others have shown that removing perineuronal nets in combination with extinction training

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity … aging, learning and memory, …

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
… The ECM has emerged as an important participant in synaptic plasticity, and in particular
the structures comprised of condensed ECM known as perineuronal nets (PNNs); [ …

[HTML][HTML] An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity

D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
plasticity-associated conditions, including memory processes. In this review, we aimed to
address how perineuronal nets … of adult brain plasticity and memory processes in physiological …

The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that … The involvement of PNNs in neuronal
plasticity has been … development and plasticity. The PNN is an important regulator of CNS …

The potential of memory enhancement through modulation of perineuronal nets

JA Duncan, R Foster, JCF Kwok - British Journal of …, 2019 - Wiley Online Library
plasticity can be restored to a juvenile-like state through modulation of a neuronal ECM
component known as perineuronal nets (… play in controlling plasticity and memory, presenting the …

Cerebellar plasticity and associative memories are controlled by perineuronal nets

D Carulli, R Broersen, F de Winter… - Proceedings of the …, 2020 - National Acad Sciences
learning that it controls. It is so far unclear whether cerebellar memory processes depend on
changes in perineuronal nets (… , which regulate neural plasticity. Here we demonstrate that …

[HTML][HTML] The extracellular matrix and perineuronal nets in memory

JW Fawcett, M Fyhn, P Jendelova, JCF Kwok… - Molecular …, 2022 - nature.com
… PNNs, either naturally (as occurs during learning), by enzymatic degradation of PNNs, or by
… act as a brake on adult brain plasticity and perhaps learning and memory performance. It is …

Perineuronal nets suppress plasticity of excitatory synapses on CA2 pyramidal neurons

KE Carstens, ML Phillips, L Pozzo-Miller… - Journal of …, 2016 - Soc Neuroscience
… Here, we present evidence that perineuronal nets (PNNs), a specialized extracellular …
plasticity-resistant excitatory CA2 synapses; thus, PNNs play a role in restricting synaptic plasticity

[HTML][HTML] Perineuronal nets affect memory and learning after synapse withdrawal

J Ruzicka, M Dalecka, K Safrankova, D Peretti… - Translational …, 2022 - nature.com
… in the control of plasticity and synapse dynamics… study was to use experimental models of
place memory to determine whether the presence of PNNs in the hippocampus affects memory