[HTML][HTML] IgA nephropathy: the lectin pathway and implications for targeted therapy

J Barratt, RA Lafayette, H Zhang, V Tesar, BH Rovin… - Kidney International, 2023 - Elsevier
… Emerging research suggests that the lectin pathway may also contribute to tubulointerstitial
… of the lectin pathway in IgAN and examines the possible therapeutic role of lectin pathway

Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease

A Roos, MP Rastaldi, N Calvaresi… - Journal of the …, 2006 - journals.lww.com
… The lectin pathway can be activated by binding of mannose-binding lectin (MBL) and ficolins
to … This study examined the potential role of the lectin pathway in IgAN. Renal biopsies of …

Current understanding of the role of complement in IgA nephropathy

N Maillard, RJ Wyatt, BA Julian, K Kiryluk… - Journal of the …, 2015 - journals.lww.com
… Of three complement-activation pathways, the alternative and lectin pathways are involved
in IgA nephropathy. IgA1 can activate both pathways in vitro, and pathway components are …

Inhibition of the lectin pathway of the complement system as a novel approach in the management of IgA vasculitis-associated nephritis

H Selvaskandan, C Kay Cheung, J Dormer, D Wimbury… - Nephron, 2020 - karger.com
IgA vasculitis can present as a glomerulonephritis histologically indistinguishable from IgA
nephropathy (IgAN). In IgAN, the alternative and lectin pathways mediate glomerular injury …

Role of complement in IgA nephropathy

MR Daha, C van Kooten - Journal of nephrology, 2016 - Springer
… The activation of C3 can also occur via the lectin pathway. In this pathway, targets of the
lectin pathway can be recognized by the pattern-like recognition molecule mannan-binding …

Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy.

M Endo, H Ohi, I Ohsawa, T Fujita… - … Official Publication of …, 1998 - academic.oup.com
lectin pathway was involved in the pathogenic mechanism of … the lectin pathway in IgA-N will
provide insights into Briefly, … /MASP-1 to prove that the lectin pathway immersed in methanol …

Activation of the lectin complement pathway in Henoch-Schönlein purpura nephritis

S Hisano, M Matsushita, T Fujita, H Iwasaki - American journal of kidney …, 2005 - Elsevier
… with IgA GN, and in those with mesangial IgA1 and IgA2 deposits, both the alternative and
lectin pathways … the lectin pathway in patients with IgA GN. Complement activation through the …

Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis

S Hisano, M Matsushita, T Fujita, Y Endo… - American journal of …, 2001 - Elsevier
lectin pathways are involved in complement activation. We first report that mesangial deposits
of IgA2 may activate the lectin pathway in patients with IgA … in childhood IgA nephropathy

New insights into the pathogenesis of IgA nephropathy

SC Yeo, CK Cheung, J Barratt - Pediatric Nephrology, 2018 - Springer
pathway (properdin and factor H) [121, 122] and lectin pathway (mannan-binding lectin (MBL…
Furthermore, the presence of lectin pathway components C4d [126,127,128] and MBL [129] …

The pathophysiology of IgA nephropathy

H Suzuki, K Kiryluk, J Novak… - Journal of the …, 2011 - journals.lww.com
… The immune complexes with IgA1 can activate complement via the alternative or lectin
pathway. The pattern of glycosylation of IgA1 and the molecular mass of IgA1-containing immune …