… DNA by the virally encoded reverse transcriptase. The viral DNA, still associated with incoming
viral … , where the viral integrase promotes the integration of the viral DNA into the host …

… that mimics one viral DNA end joined to a target DNA. Disintegration can be carried out by
the isolated catalytic core domain (CCD), since only in this instance are the viral DNA ends …

… including an IN active site mutant virus in our experiments, we have determined that LEDGF/…
, we conclude that LEDGF/p75 is a bona fide targeting factor for lentiviral DNA integration. In …

… a role for chromatin-associated LEDGF/p75 as a receptor for … virus–host interactions, the
integrase-LEDGF/p75 interface … DNA, the interaction with LEDGF/p75 encourages IN's DNA …

… of viral DNA or LEDGF/p75 is expected to yield a FRET signal. The goal of our experiments
was to compare average FRET values for IN–viral DNA and IN–LEDGF/p75 complexes and …

… not Moloney murine leukemia virus or Rous sarcoma virus IN, to an aspecific DNA. These
results … that LEDGF/p75 plays a role in the tethering of lentiviral IN to the chromosomal DNA. …

… of p75 in the viral life cycle, we tested the functional capabilities of a chromatin-binding mutant,
p75 … DNA with reporter virus–specific probes for an internal viral fragment (fig. S11A) and …

… /LEDGF/p75, that guides integration site selection by lentiviruses, the viral genus including
HIV (henceforth we use “LEDGF/p75… 24% of the amount of viral DNA seen in the control cells, …

… virus into active transcription units. Here we show that LEDGF promotes the repair of DNA
… Depletion of LEDGF impairs the recruitment of C-terminal binding protein interacting protein …

… and essential role of LEDGF/p75 in HIV replication and support the LEDGF/p75 HIV-1 … DNA
may imply a role of LEDGF/p75 in the formation of the complex between IN and the viral DNA…