Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor

N Sivasubramanian, ML Coker, KM Kurrelmeyer… - Circulation, 2001 - Am Heart Assoc
… ) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling
from 4 to 12 weeks of age. During the early phases of LV structural remodeling, there …

Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following …

WM Yarbrough, C Baicu, R Mukherjee… - … Physiology-Heart …, 2014 - journals.physiology.org
… more recently observed with left ventricular (LV) … that cardiac-specific overexpression (TIMP-4OE)
or deletion (knockout; TIMP-4KO) would differentially affect LV function and structure

Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor

M Flesch, A Höper, L Dell'Italia, K Evans, R Bond… - Circulation, 2003 - Am Heart Assoc
… in our understanding of the pathogenesis of left ventricular (LV) remodeling has been the …
by the overexpression of portfolios of biologically active molecules, including (but not limited to) …

Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging

FG Spinale, GP Escobar, R Mukherjee… - Circulation: Heart …, 2009 - Am Heart Assoc
Left ventricular (LV) remodeling is generically defined as changes in myocardial … , persistent
cardiac-restricted MT1-MMPexp was induced in mice and the effects on LV structure and …

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.

MC Colbert, DG Hall, TR Kimball… - The Journal of …, 1997 - Am Soc Clin Investig
… to severe impairment of left ventricular function and reduced cardiac contractility. Thus, …
copies per genome are present, expression is largely restricted to the ventricle and is shut down …

Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial …

S Janssens, P Pokreisz, L Schoonjans… - Circulation …, 2004 - Am Heart Assoc
… In the present study, we demonstrated that cardiac-restricted overexpression of endothelial
NOS preserves cardiac function and limits deleterious left ventricular remodeling in a mouse …

Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction

FG Spinale, R Mukherjee, JA Zavadzkas… - Journal of Biological …, 2010 - ASBMB
… of MT1-MMP overexpression (MT1-MMPexp), in a left ventricular (LV) remodeling process
… MI was then induced in mice with cardiac restricted MT1-MMPexp (n = 58) and wild type (WT…

Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B167: echocardiography and magnetic resonance imaging …

L Lottonen‐Raikaslehto, R Rissanen… - Physiological …, 2017 - Wiley Online Library
left ventricular (LV) function, but the observer dependency and limitations in acoustic access
and heart structure … (LGE) is often restricted due to contraindications to gadolinium. T 1 …

Impaired protein quality control during left ventricular remodeling in mice with cardiac restricted overexpression of tumor necrosis factor

J Hartupee, GD Szalai, W Wang, X Ma… - Circulation: Heart …, 2017 - Am Heart Assoc
… To study the relationship between chronic inflammation and protein quality control, we
used a mouse model of dilated cardiomyopathy driven by cardiac restricted overexpression of …

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

Q Li, B Li, X Wang, A Leri, KP Jana… - The Journal of …, 1997 - Am Soc Clin Investig
… The catheter was advanced into the left ventricle for evaluation of left ventricular pressures
and and dP/dt in the closedchest … These determinations were restricted to FVB.Igf/ (control, n …