… disease leishmaniasis, three semi-synthetic derivatives of natural neolignane licarin A were
… activity against the intracellular amastigotes of Leishmania (L.) infantum, with IC 50 values …

… the activity of licarin A and its derivatives against different life cycle stages of L. amazonensis,
plus the assessment of its cytotoxicity, LogP and mitochondrial membrane potential (∆Ψ). …

… leishmaniasis treatments is a necessity. This work evaluated a neolignan, licarin A anti-leishmanial …
Cell death features induced in Leishmania major by 1,3,4-thiadiazole derivatives …

… In summary, although the semi-synthetic derivatives of licarin A showed activity against T.
cruzi, their low drug-likeness limit their exploitation as prototypes for designing novel …

… derivatives were prepared from neolignans isolated from the Brazilian plant Nectandra
leucantha, and their effects against intracellular amastigotes of Leishmania (L.) infantum … licarin A …

… For example, combined therapy of botulin derivative BT06 and the betulinic acid derivative
… compound in the field of new alternative therapy for leishmaniasis (Sousa et al., 2014 ▶). In …

… Leishmaniasis is caused by several protozoan species of Leishmania, and being … Efforts
to find new, effective, and safe oral agents for the treatment of leishmaniasis are continuing …

… In addition, some strains of L. infantum are capable of causing cutaneous leishmaniasis and
not … All the organisms mentioned are zoonotic except for L. tropica, which is anthroponotic (…

… of L. major’s 14-lanosterol demethylase [37] revealed that fenarimol or its derivatives could
be used to build anti-leishmanial … major-infected macrophages treated with Licarin A [133]. …