… NLRP3 inflammasome by Leishmania parasites is critical for the outcome of leishmaniasis,
… We investigate the mechanisms involved in NLRP3 activation and demonstrate that caspase…

… NLRP3 inflammasome activation during Leishmania spp. infection is limited. Furthermore,
whether NLRP3 … lipophosphoglycan (LPG) can directly bind TLR2 to induce MAPK signaling. …

… activation of the NLRP3 inflammasome in response to Leishmania and the beneficial and …
More recently, lipophosphoglycan (LPG) from many Leishmania species was shown to trigger …

… glycoconjugate lipophosphoglycan (LPG) triggers the NLRP3 inflammasome pathway via
… pathways for the activation of the NLRP3 inflammasome during Leishmania infection and …

… The NLRP3 inflammasome has been shown … Leishmania parasites modulate NLRP3
inflammasome activation. Using PMA-differentiated THP-1 cells, we demonstrate that Leishmania …

… the host cell receptors and Leishmania effectors involved in the macrophage …
lipophosphoglycan (LPG) in this process (25). This virulence factor contributes to the ability of …

… of NLRP3 and ASC, thereby limiting NLRP3 inflammasome … restricting role of NLRP3 for
Leishmania replication, the … + Leishmania are associated with reduced inflammasome activation …

… Also, a recent paper showed non-canonical NLRP3 inflammasome activation by
lipophosphoglycan (LPG) from Leishmania membrane and casp-11 is important to the infection …

… Figure 3 IL-32 production is positively correlated with IL-1β and IL-6 production in human
cells stimulated with lipophosphoglycans from Leishmania spp. PBMCs (5 x 10 5 cells/200 µl) …

… The canonical NLRP3 inflammasome is activated upon cellular stress and perturbations in
the … , which partially contribute to NLRP3 activation upon Leishmania amazonensis infection [ …