… that involved the association between expression levels of leptin and osteoarthritis as a
primary outcome were included in this study, (2) included patients confirmed with the diagnosis …

… patients, [14,15] we hypothesized that leptin has some connections with OA caused by obesity.
Afterward, leptin … In joints of patients with severe OA, the expression of leptin and its long …

… Osteoarthritis (OA) is the most … leptin is a possible link between obesity and OA: Leptin
levels in synovial fluid are increased in obese patients, leptin receptor (Ob-R) is expressed in …

… Our immunohistochemical experiments indicated that leptin expression was up-regulated
in human OA chondrocytes. No background staining was observed in negative control studies …

… Before examining leptin effects, we investigated the baseline gene expression pattern in
both groups. The results indicated that non-stimulated chondrocytes obtained from obese …

… a key role for leptin in the pathogenesis and/or progression of OA. The goal of this focused
review is to summarize the current knowledge on the role of leptin in OA with particular …

… aims to reduce leptin expression may be a novel approach to delay OA progression in patients
with obesity or MetS. Regular and light aerobic exercise could decrease leptin levels in un…

… Interestingly, a marked expression of leptin was observed in OA cartilage, especially in …
produced leptin in normal cartilage. Furthermore, the pattern and level of leptin expression were …

… the source of leptin in OA bone tissue by measuring leptin expression and release by …
exogenous leptin could alter cell proliferation of OA Ob; and iii) evaluating if local leptin production …

… confirm the role of leptin in this group of patients. In conclusion, leptin is proportionate with
… cartilage degradation in obese patients with knee osteoarthritis, hence the severity of KOA. …