… Cell lines. We used the CML blastic crisis cell line K562 (Ph '-positive), the promyelocytic
leukemia cell line HL-60 (Ph'-negative), the acute myelogenous leukemia cell line KG-I (Ph'-…

… Bcr/Abl tyrosine kinase. METHODS: Nude mice were given an injection of the Bcr/Abl-positive
human leukemia cell … (2-5 hours) inhibition of Bcr/Abl kinase activity. On the basis of the …

… myeloid leukemia (CML) … BCR-ABL oncogene that encodes for the chimeric BCR-ABL
oncoprotein, with constitutive kinase activity that promotes the growth advantage of leukemic cells (…

… therefore be needed to induce cell death in most leukemic cells, which may interfere with …
is evidence that BCR/ABL mRNA and protein may not be expressed in CML stem cells. Ex …

… in DSBs in leukemia cells [45] . In addition, BCRABL-positive leukemia cells accumulate more
… Unfortunately, Bcr-Abl kinase may also reduce the fidelity of DSB repair mechanisms such …

… -positive chronicmyelogenous leukemia (CML) generates an aberrant bcr-abl fusion … bcr-abl
transcript, we studied the patterns of expression of the normal ber gene in different cell types…

… of chemotherapeutic agents on tumor cells, and therefore the … leukemia (CML) cell line
expressing the BCR-ABL fusion … tion start of bcr downregulate bcr-ab/ protein in these cells and …

… Our results indicate an interesting approach to treating CML, by trapping BCR–ABL in the
nucleus of leukemic cells and thus converting BCR–ABL into a terminator of this disease. …

… against v-abl transformed murine neoplastic cells (11); in … cellular effects of CGP57148B in
BCR/ ABL leukemic cells (including 14 fresh patient samples), and in BCR/ABL negative cells, …

… of BCR and ABL in t(9;22) positive leukemia cell lines, which include the normal BCR and
ABL1b … gene of the Ph chromosome (BCR-ABL) and the mRNAs of the reciprocal fusion gene (…