… site for RBPJ/Notch1 has been reported in IL7R in CUTLL1 cells (23)… cells by ChIP-Seq,
whereas local ChIP confirmed binding of Notch1 to a putative 3′ IL7R enhancer in three Notch1…

… prevents NOTCH1 nuclear localization, but most genes with NOTCH1-… % of NOTCH1-binding
sites show dynamic changes in NOTCH1 occupancy when T-lymphoblastic leukemia cells …

… with NOTCH1 or FBXW7 mutations in CLL patients (Young et al. 2017). The observation
that active Notch signaling is detectable also in CLL cases that lack NOTCH1 mutations …

… (Notch1 and Rbpj) results in the depletion of epithelial precursors that in consequence do not
promote acinar and islet cell formation and results in switching the cell … leukemia) we found …

… (A) Heat map shows enhanced RBPJ binding in MT cells upon Notch activation by infection
with plasmids encoding a biotinylatable form of the NOTCH1 intracellular domain wildtype (…

… that in some human T lymphoblastic leukemias, a chromosomal translocation resulted in a
… To investigate this further, we have now expressed the murine Notch1 intracellular domain (…

… -cell NOTCH1 cofactor. These results demonstrate the feasibility of context-dependent
suppression of NOTCH1 … recruitment of RBPJ to chromatin, we first defined “dynamic RBPJ peaks” …

… In addition, gastrointestinal toxicity and weak anti-leukemic … T cell leukemia is RBP-J that
mediates the effects of Notch1 … -ALL cell lines has been shown to antagonize Notch1 activation […

… Notch1 protein is sufficient to induce apoptosis in hexametilene-bisacetamide-differentiating
murine erythroleukemia cells. … Disruption of the mouse RBP-J kappa gene results in early …

… , RBPJ deletion occurred together with an activating NOTCH1 mutation … RBPJ and NOTCH1
disruption it was highly increased. DTX1 expression was more independent of the NOTCH1 …