Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism

AR Bonilla-Porras, M Jimenez-Del-Rio… - Cancer cell …, 2011 - Springer
… During the last decade, VC and VK3 administered in a ratio 100:1 respectively, exhibit
synergistic anti-tumor activity by a cell death process denominated autoschizis. This …

Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D

SY James, MA Williams, AC Newland… - … : The Vascular System, 1999 - Elsevier
… The similar differentiative profiles of activity of retinoids and vitamin D compounds have
prompted a number of studies into whether these compounds exhibit additive or synergistic

The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia

H Zhao, H Zhu, J Huang, Y Zhu, M Hong, H Zhu… - Leukemia research, 2018 - Elsevier
… low-dose Vitamin C and decitabine has a synergistic efficacy on proliferation, apoptosis,
TET2 expression and activity, compared to drug–alone treatment in HL60 and NB4 cell lines in …

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi …

E Elstner, M Linker-Israeli, J Le, T Umiel… - The Journal of …, 1997 - Am Soc Clin Investig
… Cancer can result from dysregulation of either cellular proliferation, differentiation, and/…
leukemic cells compared with other acute myeloid leukemias (2, 3); APL cells have prolonged cell

Synergism of interleukin 6 and 1α,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines

AJ Duits, W Dimjati, JGJ van de Winkel… - Journal of leukocyte …, 1992 - academic.oup.com
… D 3 ) on differentiation of the human myeloid leukemic cell lines U937 and HL-60 with respect
to alterations in antigen expression and functional activity. Of a panel of antigens analyzed…

Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid …

A Shabtay, H Sharabani, Z Barvish, M Kafka… - Oncology, 2008 - karger.com
… The molecular mechanism of the synergistic activity of 1,25D 3 and plant polyphenolic
antioxidants against myeloid leukemia cells has been extensively studied in our and other …

Ascorbic acid (vitamin C) synergistically enhances the therapeutic effect of targeted therapy in chronic lymphocytic leukemia

W Darwiche, C Gomila, H Ouled-Haddou… - Journal of experimental …, 2020 - Springer
… Given that CLL B-cells are known to be sensitive to oxidative … AA might effectively kill leukemic
cells and synergize with CLL … cell viability assay was performed to detect cell kill synergy. …

Enhancement by other compounds of the anti-cancer activity of vitamin D3 and its analogs

M Danilenko, GP Studzinski - Experimental cell research, 2004 - Elsevier
… of vitamin D 3 and its analogs, and discusses the possible mechanistic basis for this synergy
in … Thus, mice inoculated with L1210 lymphocytic leukemia cells, which had been pretreated …

Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia

H Sharabani, E Izumchenko, Q Wang… - … Journal of Cancer, 2006 - Wiley Online Library
… marked synergistic reduction in WEHI-3B D − cellleukemia cells,36, 40 the enhanced
antiproliferative effect of VDD/carnosic acid combinations in WEHI-3B D − murine leukemia cells is …

… -vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells

E Elstner, M Linker-Israeli, T Umiel, J Le, I Grillier… - Cancer research, 1996 - AACR
vitamin D 3 (1,25-dihydroxyvitamin D 3 ; 1,25(OH) 2 D 3 ) inhibits proliferation and induces
differentiation of myeloid leukemic cells… potential of combining a vitamin D 3 analogue, 20-epi-…