Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium

VV Glinsky, GV Glinsky, OV Glinskii, VH Huxley… - Cancer research, 2003 - AACR
… this article suggest that hematogenous cancer metastases could originate from … leukocyte
adhesion to the endothelium was shown to trigger a L-selectin-dependent homotypic leukocyte

Vascular cell adhesion molecule‐1 (VCAM‐1)—an increasing insight into its role in tumorigenicity and metastasis

M Schlesinger, G Bendas - International journal of cancer, 2015 - Wiley Online Library
… decades ago as endothelial adhesion receptor with key function for leukocyte recruitment
in … to metastatic spread, was the first and for a long time the only link of VCAM-1 to cancer

The involvement of selectins in cell adhesion, tumor progression, and metastasis

PM Sass - Cancer investigation, 1998 - Taylor & Francis
… by the cancer cell, the cellular milieu in which the cancer cell finds itself, or both? Tumor-cell
metastasis is … of leukocytes across the endothelium in response to an inflammatory cue (1,2). …

The evolving role of lymphatics in cancer metastasis

RH Farnsworth, MG Achen, SA Stacker - Current opinion in immunology, 2018 - Elsevier
… of metastatic cancer now reveal complex patterns of dissemination. The lymphatic endothelial
… a variety of immunosuppressive leucocyte subtypes in the primary tumour, sentinel LN and …

[HTML][HTML] The tumour vasculature as a target to modulate leucocyte trafficking

Y Zhao, KK Ting, P Coleman, Y Qi, J Chen, M Vadas… - Cancers, 2021 - mdpi.com
leucocyte capture onto the tumour endothelial cells (ECs), their rolling and firm adhesion
on the activated endothelium, intraluminal crawling of the leucocytes, … distant metastasis [191]. …

Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium

YJ Kim, L Borsig, HL Han, NM Varki, A Varki - The American journal of …, 1999 - Elsevier
… are believed to play a part in modulating some early events in tumor metastases. … cancer
cells with leukocytes, platelets, and endothelium during the early events of tumor metastasis.45, …

CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis

M Roblek, D Protsyuk, PF Becker, C Stefanescu… - Molecular Cancer …, 2019 - AACR
… Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-…
Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions …

Cytokines as communication signals between leukocytes and endothelial cells

A Mantovani, E Dejana - Immunology today, 1989 - cell.com
… 1 (and TNF) augmented lung metastasis from human tumor cells injected intravenously …
metastasis should be carefully considered in the evaluation of the potential of cytokines in cancer

Recent insights into endothelial control of leukocyte extravasation

PL Hordijk - Cellular and Molecular Life Sciences, 2016 - Springer
… Thus, whereas a stiffness gradient may drive spread leukocytes towards the cellular … wall
to cancer metastasis as well as cardiovascular disease [143] will be of much interest to the field. …

Role of the endothelium during tumor cell metastasis: is the endothelium a barrier or a promoter for cell invasion and metastasis?

CT Mierke - Journal of biophysics, 2008 - Wiley Online Library
… of the cancer disease [52] and supports the interaction of prostate cancer cells and endothelial
… the cytoplasm of endothelial cells similar to leukocytes, or destroy endothelial cells [81], or …