Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
C Selman, L Partridge, DJ Withers - PloS one, 2011 - journals.plos.org
… lifespan in a second, separate cohort of Irs1 null female mice… deletion of Irs1 significantly
extends lifespan in female mice. … study demonstrates lifespan extension in male Irs1 null mice. …
extends lifespan in female mice. … study demonstrates lifespan extension in male Irs1 null mice. …
Genetic mouse models of extended lifespan
… expressed specifically in the adipose tissue leading to the deletion of exon 4 of the IR receptor.
… Because dwarf mice share some phenotypes with calorie-restricted mice, such as small …
… Because dwarf mice share some phenotypes with calorie-restricted mice, such as small …
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
AR Choudhury, Z Ju, MW Djojosubroto, A Schienke… - Nature …, 2007 - nature.com
… of these phenotypes in our cohort of aging iG4 Cdkn1a +/+ mice on a … /− mice suggested
that Cdkn1a deletion improves stem and progenitor cell function in these compartments in mice …
that Cdkn1a deletion improves stem and progenitor cell function in these compartments in mice …
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
… phenotype and early death of constitutive Bmal1−/− mice is … phenotypes and increased
the lifespan of Bmal1cKO mice, … –neuron coupling underlie the phenotypes of our mutants. …
the lifespan of Bmal1cKO mice, … –neuron coupling underlie the phenotypes of our mutants. …
A comprehensive analysis of replicative lifespan in 4,698 single-gene deletion strains uncovers conserved mechanisms of aging
MA McCormick, JR Delaney, M Tsuchiya… - Cell metabolism, 2015 - cell.com
… of 4,698 viable single-gene deletion strains. Multiple functional gene … , deletion of tRNA
exporter LOS1 robustly extended lifespan. … Moreover, lifespan extension from deletion of LOS1 is …
exporter LOS1 robustly extended lifespan. … Moreover, lifespan extension from deletion of LOS1 is …
P66 SHC deletion improves fertility and progeric phenotype of late‐generation TERC‐deficient mice but not their short lifespan
M Giorgio, M Stendardo, E Migliaccio, PG Pelicci - Aging Cell, 2016 - Wiley Online Library
… We could also determine the lifespan of G6 TERC −/− p66SHC −/− mice, revealing a
further shortening of lifespan with respect to the G3 (Fig. 6C). Necroscopic examination of …
further shortening of lifespan with respect to the G3 (Fig. 6C). Necroscopic examination of …
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and …
KT Coschigano, AN Holland, ME Riders, EO List… - …, 2003 - academic.oup.com
… In summary, although the GHA and GHR −/− mice shared a dwarf phenotype, differences …
life span extension, may be explained by their different degrees of GH signaling. This life span …
life span extension, may be explained by their different degrees of GH signaling. This life span …
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
K Flurkey, J Papaconstantinou… - Proceedings of the …, 2001 - National Acad Sciences
… deletion of the p66 shc signal transduction protein has been shown to lead to increased
lifespan … It therefore will be useful to study lifespan and age-sensitive phenotypes in dw/dw mice …
lifespan … It therefore will be useful to study lifespan and age-sensitive phenotypes in dw/dw mice …
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
C Selman, S Lingard, AI Choudhury… - The FASEB …, 2008 - Wiley Online Library
… that deletion of Irs1 but not Irs2 extends life span in female mice… mice extends life span and
concomitantly impairs insulin action (44). In contrast, deletion of Klotho results in a phenotype …
concomitantly impairs insulin action (44). In contrast, deletion of Klotho results in a phenotype …
The 22q11. 2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan
RK Jonas, CA Montojo, CE Bearden - Biological psychiatry, 2014 - Elsevier
… phenotypes in 22q11.2 deletion syndrome (22q11DS). (A) As a conceptual illustration of the
variability of neuropsychiatric phenotypes in … in mouse models with hemizygous deletion of …
variability of neuropsychiatric phenotypes in … in mouse models with hemizygous deletion of …
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- dysfunctional telomeres lifespan of mice
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- insulin receptor substrate mice with deletion