… lifespan in a second, separate cohort of Irs1 null female mice… deletion of Irs1 significantly
extends lifespan in female mice. … study demonstrates lifespan extension in male Irs1 null mice. …

… expressed specifically in the adipose tissue leading to the deletion of exon 4 of the IR receptor.
… Because dwarf mice share some phenotypes with calorie-restricted mice, such as small …

… of these phenotypes in our cohort of aging iG4 Cdkn1a +/+ mice on a … /− mice suggested
that Cdkn1a deletion improves stem and progenitor cell function in these compartments in mice …

… phenotype and early death of constitutive Bmal1−/− mice is … phenotypes and increased
the lifespan of Bmal1cKO mice, … –neuron coupling underlie the phenotypes of our mutants. …

… of 4,698 viable single-gene deletion strains. Multiple functional gene … , deletion of tRNA
exporter LOS1 robustly extended lifespan. … Moreover, lifespan extension from deletion of LOS1 is …

… We could also determine the lifespan of G6 TERC −/− p66SHC −/− mice, revealing a
further shortening of lifespan with respect to the G3 (Fig. 6C). Necroscopic examination of …

… In summary, although the GHA and GHR −/− mice shared a dwarf phenotype, differences …
life span extension, may be explained by their different degrees of GH signaling. This life span …

… deletion of the p66 shc signal transduction protein has been shown to lead to increased
lifespan … It therefore will be useful to study lifespan and age-sensitive phenotypes in dw/dw mice …

… that deletion of Irs1 but not Irs2 extends life span in female mice… mice extends life span and
concomitantly impairs insulin action (44). In contrast, deletion of Klotho results in a phenotype …

… phenotypes in 22q11.2 deletion syndrome (22q11DS). (A) As a conceptual illustration of the
variability of neuropsychiatric phenotypes in … in mouse models with hemizygous deletion of …