… antibodies, decoy receptors, as well as novel strategies to target TAM ligands are being
developed. This paper will review the biology of TAM receptors and their ligands with a focus on …

Toll-like receptors (TLRs) have a crucial role in regulating immunity against microbial agents.
Recent studies indicate that these receptors might also have an important role in regulating …

… NRTN were found to signal through a multicomponent receptor system comprising a high-affinity
ligand-binding co-receptor GFRα (GDNF family receptor α-component) and the RET …

… signaling via different receptors. It is also becoming clear that other VEGF ligands such as
… We also discuss recent findings demonstrating that other VEGF ligands influence processes …

… Recently, we identified a synthetic RORα/γ inverse agonist in a nuclear receptor specificity
screen of known nuclear receptor ligands. T0901317, a known and well characterized LXRα …

… Peroxisome proliferator-activated receptors are ligand-activated transcription factors that
regulate … of ligand-activated nuclear hormone receptors (NRs) belonging to the steroid receptor …

… The x-ray structure analysis of both receptors in complex with the same ligand (R1881,
Fig.2) should increase our understanding of ligand specificities. Furthermore, the analysis of …

… A chimeric receptor, AR-UR, in which the androgen receptor ligand-binding … UR ligand-binding
domain, was activated by a known UR ligand, CAM (400 nM). Reporter gene activation …

… by the covalently bound ligand, which allows detection of photons. Moreover, in a K296G
mutant receptor, an artificial amine ligand binds and activates as a strictly diffusible ligand (60). …

… Therefore, we describe the current status of our understanding of the ligand-binding
mechanism and receptor activation, and derive from this principles that are useful for drug design (…