… Here, we show that lin-28 is repressed during normal development by a mechanism that
acts on its mRNA after translation initiation. We provide evidence that lin-14 inhibits a negative …

… Lin28-dependent stimulation of translation in a reporter system [15]. To determine whether
EEF1G, HMGA1, and RPS13 mRNAs also contain LREs, we initiated … the translation in a Lin28…

… To evaluate the interaction between the translation initiation factor eIF3β and Lin-28 under
physiological conditions, we have immunoprecipitated eIF3β from differentiating PMs and …

… lin-28 is also regulated at this stage by lin-4 and lin-14. (B) In the let-7-dependent pathway,
… Additionally, LIN28 can bind the translation initiation factor eIF3β, although how this …

… LIN28 is a key translational determinant of the initiation of hESC differentiation. Although
most of the LIN28-… The cold shock domain protein LIN-28 controls developmental timing in C. …

… Current insights into Lin28 rest heavily on precedents in C. elegans genetics. Lin-28 was
first … let-7 homologs phenocopied lin-28 gain of function in the hypodermal stem cells and lin-…

… Lin28 as a target-specific translational regulator (15–17), the precise mechanism underlying
the process is unclear. The finding that Lin28 interacts with the translation initiation … vivo (28)…

… through interactions with translation initiation complexes. In human … Lin28 was shown to
be more resistant to paclitaxel. While stable expression of Lin28 in cancer cells with low Lin 28 …

… Lin-28 was first identified in C. elegans as a heterochronic factor that regulates … -induced
HCC initiation. To determine if LIN28 proteins are required for tumor initiation, we generated …

… of lin-4 RNA with the 3 UTR of lin-14 mRNA permits normal biogenesis of lin-14 mRNA, and
normal translational initiation, … lin-4 also represses translation of lin-28 mRNA, and lin-28 is …