… the cell commitment to a particular lineage are still poorly understood. In acute leukemia cell
… Leukemic cells present genetic and immunophenotypic patterns that are characteristic for …

… cells can induce in vitro differentiation into myeloid cells, with C/EBPα and PAX5 playing
antagonistic roles in myeloid and B-lymphoid lineage commitment, respectively. …

… Starting in the very primitive multipotential hematopoietic stem cells (HSC), lineage
commitment proceeds after a gradual process of cell differentiation and concomitant series of …

… or monoblastic AML (acute myeloid leukemia) subtypes. … In this study, from a series of 363
acute leukemia patient … to numerous specific subtypes of acute leukemias, (ii) discriminate t(…

… (ALs) with phenotypic and genotypic features of several hematopoietic lineages are … of
acute leukemia (109 acute myelogenous leukemia, AML, and 91 acute lymphoblastic leukemia, …

… Classification of acute leukemia involves assigning lineage by … Acute leukemias of ambiguous
lineage (ALALs) are those … lineage commitment or show evidence of commitment to more …

… lineage commitment or show evidence of commitment to … that certain acute leukemias fail
to conform to single lineage … proposed in the 1990s to diagnose biphenotypic leukemias. …

… acute leukemia (AL) adheres to the original lineage, despite minor changes in some markers.
However, complete lineage … Recent studies suggest that lineage commitment of plastic …

… Rare cases may fulfill neither the criteria for MPAL nor acute leukemia of a single lineage or
may lack all the lineage-specific markers of Table 2. Such cases are best referred to as ALAL…

… in leukemic myeloblasts. Individual examples of truly aberrant gene expression may well
occur in leukemia but … We suggest that verifiable and consistent examples of apparent lineage …