… cells containing Beclin-1 K117R had little associated K63-linked ubiquitin as … Beclin-1 (Fig.
5B). Next, we compared wild-type and Beclin-1 K117R proteins in an in vitro ubiquitination …

… ligase, could interact with BECN1 and promote the K48-linked ubiquitination and
degradation of this protein; In addition, CUL3 led to a decrease in autophagic activity through …

… -linked ubiquitination of Beclin 1 and disruption of the interaction with BCL-2 is necessary
for macrophages in order to clear pathogens by autophagy upon pathogen encounter. It is …

… ‐linked ubiquitination of Beclin 1, we performed an in vitro … However, we found that the
K63‐linked ubiquitination of Beclin 1 … ligase for K63‐linked ubiquitination of Beclin 1 in starvation‐…

… ubiquitination of K117A Beclin 1 to wild-type Beclin 1, we conclude that K117 of Beclin 1 is
a major target for linking ubiquitin … that K63-linked ubiquitination facilitates Beclin 1-Beclin 1 …

… BECLIN 1 and modulates the activity of the PI3K-III complex. Here we discuss the regulation
of BECLIN 1 by several different types of ubiquitination… -linked ubiquitination of BECLIN 1 [67…

… stabilizes the beclin 1-VPS34 interaction by binding to beclin 1 [50]. … 1/cullin 4 (RBX1/CUL4)
-ligase also acts as an E3 ubiquitin ligase to mediate K63 linked ubiquitination of beclin 1 to …

… To demonstrate that Akt-mediated USP14 phosphorylation inhibits autophagy through Beclin
1 K63-linked deubiquitination, we overexpressed wild-type USP14 or mutants together with …

… We find that S-phase kinase-associated protein 2 (SKP2) executes lysine-48-linked poly-ubiquitination
of … Using a set of ubiquitin mutants, we found that SKP2 leads to K48-linked poly-…

… In the present study we describe a regulatory link between Beclin 1 and the ubiquitin ligase
Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). We establish …