Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

AE Justice, T Karaderi, HM Highland, KL Young… - Nature …, 2019 - nature.com
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …

Lipid homeostasis, lipotoxicity and the metabolic syndrome

RH Unger, GO Clark, PE Scherer, L Orci - … and Cell Biology of Lipids, 2010 - Elsevier
body mass index (BMI) of less than 28 kg/m 2 . Nevertheless, in some patients there was a
subtle increase in body fat… also interfere with normal lipid partitioning into fat cells, as could …

Leptin regulation of lipid homeostasis: dietary and metabolic implications

KL Houseknecht, ME Spurlock - Nutrition research reviews, 2003 - cambridge.org
… regulation of lipid homeostasis as well as the impact of nutrition in the regulation of leptin
biology. … high relative to body fat mass in rats fed diets supplemented with n-3 polyunsaturated …

Role of the gut in lipid homeostasis

NA Abumrad, NO Davidson - Physiological reviews, 2012 - journals.physiology.org
… acid absorption, NPC1L1 in cholesterol absorption, as well as other lipid transporters …
of intestinal lipid homeostasis through recent findings on the role of lipid flux and fatty acid …

Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue

YH Yu, HN Ginsberg - Circulation research, 2005 - Am Heart Assoc
… mice with less body fat, increased whole-body insulin sensitivity, and resistance to age- and
obesity-related insulin resistance, despite a clear lack of insulin stimulated glucose and lipid

Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis

PW Caton, EA Evans, MP Philpott… - Current Opinion in …, 2017 - Elsevier
… and metabolic homeostasis SAT is the largest adipose tissue depot and as a result plays
a key role in regulating whole-body glucose and lipid homeostasis via its endocrine and lipid

Mitochondrial dysfunction and lipid homeostasis

J Vamecq, AF Dessein, M Fontaine… - Current drug …, 2012 - ingentaconnect.com
… In this respect, it is now well documented that insulin resistance is linked to increased levels
of circulating free fatty acids more than to increased body fat contents. Elevated circulating …

Lipid homeostasis in exercise

M Bosma - Drug discovery today, 2014 - Elsevier
… mitochondrial oxidative metabolism and lipid droplet (LD) dynamics. In this review, I discuss
lipid homeostasis during acute exercise and adaptations in lipid metabolism upon exercise …

Organismal carbohydrate and lipid homeostasis

DG Hardie - Cold Spring Harbor perspectives in biology, 2012 - cshperspectives.cshlp.org
… In this section, the critical endocrine glands and nerve centers involved in regulation of
whole body energy homeostasis, and the hormones and cytokines they produce, are briefly …

Autophagy: Emerging roles in lipid homeostasis and metabolic control

P Christian, J Sacco, K Adeli - … (BBA)-Molecular and Cell Biology of Lipids, 2013 - Elsevier
lipid homeostasis in … of lipid stores controlling triglyceride homeostasis and fatty liver. Taken
together, autophagy appears to play a very complex role in lipid homeostasis, affecting lipid