… to speculate that the accumulation of lipids in tissues not suited for fat storage (eg, … of
insulin resistance and the metabolic syndrome. We review the metabolic fates of lipids in insulin-…

… effects on insulin action… lipids precipitate the development of insulin resistance. This review
summarises the evidence linking specific lipid molecules to the induction of insulin resistance…

… , inflammation and adipocyte function should identify the roles of circulating lipid mediators
in obesity, insulin resistance and metabolic dysfunction. Current studies do not establish that …

… (SkM) insulin resistance has been attributed to lipids and … of various lipid-derived mediators
on SkM insulin sensitivity. … biogenesis of intramyocellular ectopic lipid stores are discussed. …

… insulin resistance in obese models; however, it is not the only mechanism whereby TNF may
mediate insulin resistance… of the gene encoding the insulin-responsive glucose transporter, …

… Insulin resistance is defined as a reduced response of … lipid mediators by lipoxygenases
and cyclooxygenases. The different derivatives and biological actions of these lipid mediators …

… on the role of lipid mediators. In this review, we speculate that lipid mediators act on important
… insulin action and initiate insulin resistance, hyperglycemia and metabolic dysfunction. …

… Conversely, inflammatory signaling can significantly alter lipid metabolism … Introduction
Insulin resistance is a major metabolic … be metabolized to small lipid mediators termed ‘‘protectins/…

… (PKCζλ, β2, γ) or inhibitors (PKCζλ, α, δ, θ, ε, β1) of the insulin signal, depending on … insulin
resistant obesity, highlighting PKC isoforms as regulators of lipid-induced insulin resistance …

… and insulin resistance 15,16 . Of … of lipids — ceramides — as drivers of insulin resistance
has also been proposed, since inhibition of ceramide biosynthesis attenuated insulin resistance…