Ion pair transport across membranes

R Neubert - Pharmaceutical research, 1989 - Springer
… discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown
to … The transport of ion pairs across lipid membranes (ion pair transport) appears to follow a …

Ion Pairing of Cationic and Anionic Ir(III) Photosensitizers for Photocatalytic CO2 Reduction at LipidMembrane Surfaces

S Takizawa, T Okuyama, S Yamazaki… - Journal of the …, 2023 - ACS Publications
… Herein, we report the synthesis of [Ir1 + ][Ir2 – ] as a new ion pair and … -3-phosphocholine
(DPPC) vesicle membranes, by comparing the … effect of ion pairing at the vesicle membrane. …

Free Energy for the Permeation of Na+ and Cl Ions and Their Ion-Pair through a Zwitterionic Dimyristoyl Phosphatidylcholine Lipid Bilayer by Umbrella Integration …

IV Khavrutskii, AA Gorfe, B Lu… - Journal of the American …, 2009 - ACS Publications
… kcal/mol near its center, ion-pairing between such hydrophilic ions as Na + and Cl − does …
that ion-pairing between ions of opposite charge and solvent philicity could enhance ion

Recent progress in hydrophobic ion-pairing and lipid-based drug delivery systems for enhanced oral delivery of biopharmaceuticals

G Noh, T Keum, S Bashyal, JE Seo, L Shrawani… - Journal of …, 2022 - Springer
… However, only lipophilic substances can be stably incorporated in LDDSs, and
hydrophilic peptides and proteins require lipidation via, eg, hydrophobic ion pairing (HIP). …

Applications of the ion-pair concept to hydrophilic substances with special emphasis on peptides

D Quintanar-Guerrero, E Allémann, H Fessi… - Pharmaceutical …, 1997 - Springer
… parameters involved in ion pair formation with special … of drugs, and on the enhanced
absorption as ion-pairs. Results from … that ionic drug transport across an artificial lipid membrane

[HTML][HTML] Counterion-mediated membrane penetration: cationic cell-penetrating peptides overcome Born energy barrier by ion-pairing with phospholipids

EK Esbjörner, P Lincoln, B Nordén - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
… to explore if solvation by ion-pairing to hydrophobic counter-ions may serve as a mechanism
for cell internalisation. We demonstrate that anionic lipids can aid peptide partitioning into …

The dermal delivery of lignocaine: influence of ion pairing

C Valenta, U Siman, M Kratzel, J Hadgraft - International journal of …, 2000 - Elsevier
… The purpose of the present study was to determine the significance of ion pairing on the
permeation of lignocaine. Results of diffusion studies through polydimethylsiloxane (PDMS) at …

Ion pair-mediated transport of metoprolol across a three lipid-component PAMPA system

ZS Teksin, K Hom, A Balakrishnan, JE Polli - Journal of controlled release, 2006 - Elsevier
… Potential ion pair-mediated transport of metoprolol was challenged via a self-… ion pairing
as a mechanism to enhance metoprolol transport across A-PAMPA and assumed that ion pair-…

[HTML][HTML] Distribution of ion pairs into a bilayer lipid membrane and its effect on the ionic permeability

T Omatsu, K Hori, N Ishida, K Maeda… - Biochimica et Biophysica …, 2021 - Elsevier
… validate the ion-pair distribution model for ionic membrane transport through a BLM based
on the distribution cation and anion by evaluating the distribution constant of ions between an …

Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery

R Ismail, TNQ Phan, F Laffleur, I Csóka… - European journal of …, 2020 - Elsevier
… The lipophilic character of peptides can be tremendously improved by hydrophobic ion
pairing (HIP) with counterions to be efficiently incorporated into lipid-based nanocarriers (NCs). …