[HTML][HTML] Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

J Swierczynski, A Hebanowska… - World journal of …, 2014 - ncbi.nlm.nih.gov
… the changes in lipid metabolism in pancreatic ductal adenocarcinoma, the most common
pancreatic neoplasm, with very high mortality. The potential role of elevated lipid synthesis in …

[HTML][HTML] Lipid metabolism and lipid droplets in pancreatic cancer and stellate cells

Y Sunami, A Rebelo, J Kleeff - Cancers, 2017 - mdpi.com
… in pancreatic cancer … in pancreatic cancer focusing on lipid metabolism are discussed.
Furthermore, we summarize several preclinical studies and clinical trials, also from other cancer

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

X Yin, R Xu, J Song, R Ruze, Y Chen… - Cancer …, 2022 - Wiley Online Library
… targeting lipid metabolic systems in pancreatic cancer. Finally, we highlight the challenges
and … for targeting lipid metabolism pathways through precision therapies in pancreatic cancer. …

SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism

Y Sun, W He, M Luo, Y Zhou, G Chang, W Ren, K Wu… - Tumor Biology, 2015 - Springer
… in tumorigenesis, yet its role in pancreatic cancer remains unclear. Here, we explored the …
of SREBP1 in pancreatic cancer. Analysis of 60 patients with pancreatic ducat cancer showed …

Development and validation of a four‐lipid metabolism gene signature for diagnosis of pancreatic cancer

Y Ye, Z Chen, Y Shen, Y Qin, H Wang - FEBS Open Bio, 2021 - Wiley Online Library
… certain genes related to lipid metabolism encode important … pancreatic cancer datasets
from The Cancer Genome Atlas and searched for prognostic genes related to lipid metabolism in …

HSDL2 acts as a promoter in pancreatic cancer by regulating cell proliferation and lipid metabolism

A Han, R Xu, Y Liu, X Yin, Z Lin… - OncoTargets and therapy, 2021 - Taylor & Francis
… in cell growth and lipid metabolism of PC remains unclear. … triggered the tumorigenesis
through lipid metabolism in PC. In … may promote progression of PC through lipid metabolism. …

KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL

CN Rozeveld, KM Johnson, L Zhang, GL Razidlo - Cancer research, 2020 - AACR
… HSL to control metabolism in metastatic pancreatic cancer cells by regulating lipid storage
and … shift away from FA oxidation in pancreatic cancer cells, leading to LD accumulation and …

[HTML][HTML] Lipid metabolism in cancer: New perspectives and emerging mechanisms

LA Broadfield, AA Pane, A Talebi, JV Swinnen… - Developmental cell, 2021 - cell.com
… on cancer lipid metabolism has … lipid metabolism for anti-cancer therapies is attractive,
with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. …

[HTML][HTML] Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism

JH Lee, Y Cho, JH Kim, J Kim, HY Nam… - … & molecular medicine, 2019 - nature.com
metabolism in lipid metabolism 37,38 , we observed that inhibition of BCAA metabolism
suppressed lipid metabolism. … Glutamine contributes to citrate and lipid metabolism through TCA …

[HTML][HTML] Development of a lipid metabolism-related gene model to predict prognosis in patients with pancreatic cancer

H Xu, J Sun, L Zhou, QC Du, HY Zhu… - World Journal of …, 2021 - ncbi.nlm.nih.gov
… of 197 lipid metabolism-related genes in pancreatic cancer tissues and their relationship
with OS. We developed a novel prognostic model integrating 4 lipid metabolism-related genes …