Lipid nanoparticlemRNA formulations for therapeutic applications

C Wang, Y Zhang, Y Dong - Accounts of chemical research, 2021 - ACS Publications
… we believe that more and more lipidmRNA nanoparticle formulations will enter the clinic in
… vitamin C lipid nanoparticle (VcLNP) and applied the VcLNP–mRNA formulation to engineer …

[HTML][HTML] Lipid nanoparticles for mRNA delivery

X Hou, T Zaks, R Langer, Y Dong - Nature Reviews Materials, 2021 - nature.com
… clinical translation of lipid nanoparticlemRNA formulations, … clinical studies of lipid
nanoparticlemRNA therapeutics for … examples of lipid nanoparticlemRNA formulations in clinical …

Principles for designing an optimal mRNA lipid nanoparticle vaccine

E Kon, U Elia, D Peer - Current opinion in biotechnology, 2022 - Elsevier
… sequence design and nucleotide modification choice, (2) Optimization of a LNP formulation
to encapsulate and deliver mRNA and (3) long-term storage. Each one of these phases …

Lipid nanoparticle formulations for enhanced co-delivery of siRNA and mRNA

RL Ball, KA Hajj, J Vizelman, P Bajaj… - Nano letters, 2018 - ACS Publications
mRNA in a single lipidoid nanoparticle (LNP) formulation. We accommodated the distinct
molecular characteristics of mRNA and siRNA in a formulation … PEG-lipid. Surprisingly, the co-…

[HTML][HTML] mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

L Schoenmaker, D Witzigmann, JA Kulkarni… - International journal of …, 2021 - Elsevier
… (mRNA) strands encapsulated in lipid nanoparticles (LNPs). The efficacy of these mRNA
vaccines … This review outlines how different aspects of the current mRNA vaccine formulations

Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs

KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein… - Nano …, 2015 - ACS Publications
lipid or lipid-like material, phospholipid, cholesterol, and lipid-… on the formulation potency.
Here, we develop a generalized strategy to optimize lipid nanoparticle formulations for mRNA

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

H Muramatsu, K Lam, C Bajusz, D Laczkó, K Karikó… - Molecular Therapy, 2022 - cell.com
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to
be very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic. …

Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy

MA Oberli, AM Reichmuth, JR Dorkin, MJ Mitchell… - Nano …, 2017 - ACS Publications
… Treatment of B16F10 melanoma tumors with lipid nanoparticles containing mRNA coding …
, the lipid nanoparticle formulation presented here is a promising vector for mRNA vaccine …

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

AK Blakney, PF McKay, BI Yus, Y Aldon, RJ Shattock - Gene therapy, 2019 - nature.com
… LNP formulations with cationic and ionizable lipids with … We show that LNPs formulated
with cationic lipids protect saRNA … lipids based on their properties and previous use in mRNA

Lipid nanoparticle delivery systems to enable mRNA-based therapeutics

SC Semple, R Leone, CJ Barbosa, YK Tam, PJC Lin - Pharmaceutics, 2022 - mdpi.com
… of mRNA-LNP products, including mRNA-1944 (an LNP formulation of two mRNAs encoding
… virus) [106], mRNA-3927 (an LNP formulation of two mRNAs encoding the alpha and beta …