Nanomedicine's transformative impact on anti-diabetic drug discovery: an appraisal

K Saini, S Sharma - Journal of Nanoparticle Research, 2023 - Springer
nanoparticles and enhanced sustained activity and bioavailability were observed in contrast
with plain gliclazide in the streptozotocin-… , embedded in the lipid nanoparticles (SLNs and …

Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in Type-2 diabetes

RM El-Gharbawy, AM Emara, SES Abu-Risha - Biomedicine & …, 2016 - Elsevier
… was to use Zinc oxide nanoparticles and a standard … nanoparticles (ZnONPs) using a model
of type 2 diabetes (rats fed a high fat diet that was treated with a low dose of streptozotocin). …

Nanotechnology advanced strategies for the management of diabetes mellitus

AM Mohsen - Current Drug Targets, 2019 - ingentaconnect.com
… effect of nanothymoquinone in streptozotocin-nicotinamide induced type-2 diabetes in rats
… Solid lipid nanoparticles and nanostructured lipid carriers of tolnaftate: design, optimization …

Chitosan-stabilized selenium nanoparticles alleviate cardio-hepatic damage in type 2 diabetes mellitus model via regulation of caspase, Bax/Bcl-2, and Fas/FasL …

AAR Mohamed, SI Khater, AH Arisha, MMM Metwally… - Gene, 2021 - Elsevier
… In this study, an observable serum lipid profiles in HFD/STZ induced diabetic rats was
observed. Whereas, the oral CTS-Se-NPs administration even through monotherapy and …

Formulation and development of nanoparticulate system containing rutin from leaves extract of Aegle marmelos for effective management of diabetes

N Salvi, R Khan - Research Journal of Pharmacy and …, 2023 - indianjournals.com
… Solid lipid nanoparticles have enormous effect in loading … Nicotinamide solution: Nicotinamide
arrangement was newly … course and following 15 minutes, Streptozotocin 60 mg/kg IP. …

Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats

N Kamaraj, K Velumani, A Guru, PK Issac - Molecular Biology Reports, 2023 - Springer
Background Diabetic Mellitus is characterized by a lack or failure of insulin to bind to its
target receptor or failure of the pancreas to yield insulin. This study evaluated the …

Echinacea purpurea Ethanol Extract Improves Male Reproductive Dysfunction With StreptozotocinNicotinamide-Induced Diabetic Rats

CF Mao, S Sudirman, CC Lee, D Tsou… - Frontiers in veterinary …, 2021 - frontiersin.org
… The diabetic rat model was intraperitoneally induced by streptozotocin (STZ, 65 mg/kg) and
nicotinamide (NA, 230 mg/kg) according to a previous method. The diabetes condition was …

Antioxidant, anti-inflammatory and hypoglycemic effects of Fagonia olivieri DC on STZ-nicotinamide induced diabetic rats-in vivo and in vitro study

U Rashid, MR Khan, M Sajid - Journal of ethnopharmacology, 2019 - Elsevier
… kidneys and lowered the level of transaminases, lipids, nitrogenous compounds and pro-inflammatory
cytokines in the serum of STZ-nicotinamide prompted diabetic rats. Decrease in …

Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats

F Mostafa, A Abdel-Moneim, M Abdul-Hamid… - Journal of Molecular …, 2021 - Springer
… The treatment agents also suppressed the elevated lipid … by a single intraperitoneal (ip)
STZ injection (50 mg/kg b. wt.; … Seven days after NA/STZ injection, fasting blood glucose …

The Aqueous Extract of Withania coagulans Fruit Partially Reverses Nicotinamide/Streptozotocin-Induced Diabetes Mellitus in Rats

K Shukla, P Dikshit, R Shukla… - Journal of medicinal …, 2012 - liebertpub.com
Nicotinamide followed by STZ (intraperitoneally) was used to induce experimental DM in
rats in this study. STZ contains a nitroso moiety and liberates nitric oxide and free radicals, …