Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid

SJ Lim, CK Kim - International journal of pharmaceutics, 2002 - Elsevier
formulation parameters on the physicochemical characteristics of drug-loaded SLNs should
be investigated for each drug to get a SLN formulation … prepare SLN formulation loaded with …

Skin localization of lipid nanoparticles (SLN/NLC): focusing the influence of formulation parameters

G Amasya, G Sandri, A Onay-Besikci… - Current drug …, 2016 - ingentaconnect.com
… The CLSM images clearly show that the Tripalmitin based lipid nanoparticles have higher
… coded lipid nanoparticle formulation. Additionally cellular uptake of this NLC formulation is …

Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables

S Das, WK Ng, P Kanaujia, S Kim, RBH Tan - Colloids and surfaces b …, 2011 - Elsevier
lipid nanoparticles (SLNs) of a hydrophobic drug, tretinoin, by emulsification–ultrasonication
method. Solubility of tretinoin in the solid lipids … In this study, the formulation parameters, …

Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review

S Cunha, CP Costa, JN Moreira, JMS Lobo… - … , Biology and Medicine, 2020 - Elsevier
parameters (CPPs): production parameters that affect CQAs and should be controlled. For
example, parameters … the development of lipid nanoparticles formulations, promoting efficient …

Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters

AJ Almeida, S Runge, RH Müller - International journal of pharmaceutics, 1997 - Elsevier
lipid phase of the final preparation. The influence of formulation parameters (eg type of lipid,
… This study shows that some proteins are able to endure the harsh procedures of formulation

Experimental design for the optimization of lipid nanoparticles

J Zhang, Y Fan, E Smith - Journal of pharmaceutical sciences, 2009 - Elsevier
parameters, including injected solvent, lipid concentration, surfactant concentration, temperature,
and stirring speed. Our study showed that lipid … the cooling of the formulation. The high …

[HTML][HTML] Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by dual centrifugation

D Steiner, H Bunjes - International Journal of Pharmaceutics: X, 2021 - Elsevier
… high quality lipid nanoemulsions and solid lipid nanoparticles can be prepared from lipids with
… as a screening tool for this type of lipid formulations. The manufacturing process would be …

[HTML][HTML] Influence of formulation parameters on the physicochemical properties of meloxicam-loaded solid lipid nanoparticles

RM Khalil, A Abd El-Bary, MA Kassem… - Egyptian …, 2013 - journals.lww.com
Objective The aim of this research was to investigate novel particulate carrier systems such
as solid lipid nanoparticles (SLNs) for topical delivery of a lipophilic drug, meloxicam (MLX). …

Preparation of solid lipid nanoparticles and nanostructured lipid carriers for drug delivery and the effects of preparation parameters of solvent injection method

VA Duong, TTL Nguyen, HJ Maeng - Molecules, 2020 - mdpi.com
Parameters affecting the production and properties of SLNs and NLCs can be classified as
… process parameters and formulation parameters. Preparation process parameters include …

Multivariate design for the evaluation of lipid and surfactant composition effect for optimisation of lipid nanoparticles

S Martins, I Tho, E Souto, D Ferreira… - European journal of …, 2012 - Elsevier
… of LN that could be achieved with a certain lipid/surfactant combination and concentration.
The … LN formulations without the need of extensive empirical testing of formulation parameters