… Targeting noncanonical inflammasome activation by cytosolic LPS may be effective for the
clinical treatment of sepsis and septic shock. Lipopolysaccharide (LPS) sensing in the cytosol …

… In this review we present natural and synthetic molecules active in inhibiting TLR4-mediated
LPS signalling in humans and their therapeutic potential. New pharmacological …

… intracellular LPS signaling has shown potential in mouse sepsis models. In this review paper,
we will focus discussion on how intracellular LPS is a relevant, novel therapeutic target in …

… LPS sensing in the bloodstream, including binding LPS to circulating lipoproteins, LPS …
natural and acquired antibodies), and efficient LPS clearance and inactivation by the liver and …

… This review summarizes the main features of LPS structure, function, and biosynthesis,
highlighting the potential target reactions that have been or might be exploited for therapeutic …

… , and others have been used for biosensing of LPS and have shown attractive results. This
review … in sensing of LPS with emphasis given mainly to electrochemical and optical sensing. …

… This review aims to summarize the current knowledge on the intracellular mechanisms of
LPS detection and its capacity to activate the inflammasome. The review also presents the …

… lipopolysaccharide induces the ever more complex syndrome of sepsis and the potential for
the development of novel sepsis therapeutics. … as a potential drug target in the treatment of …

… In a capsule, despite LPS being a good target identified … in potential therapeutics development.
Therefore, this article summarises the LPS synthesis and also highlights the drug targets …

… with their resistance to LPS, and HMGB1 release requires the inflammasome components
… , and ASC-deficient mice were also resistant to LPSinduced sepsis45,46. However, caspase-…