Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders

JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
… via LOX-1 upregulates Ang II type 1 receptor expression and Ang II transcriptionally
upregulates the expression of LOX-1. Shear stress, endothelin and TNF-α also upregulate LOX-1. …

Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Lox-1 inhibitors and neutralizing antibodies with promising results in animal models has
made Lox-1 a … In this review, we discuss the main findings regarding the role of Lox-1 in the …

Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in atherogenesis: a brief review

AB Reiss, K Anwar, P Wirkowski - Current medicinal chemistry, 2009 - ingentaconnect.com
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that
primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is …

Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene

M Nagase, J Abe, K Takahashi, J Ando, S Hirose… - Journal of Biological …, 1998 - ASBMB
… regulation of LOX-1 gene has not yet been clarified. In the present study, we isolated the
rat LOX-1 gene and investigated the regulation of gene expression. The rat LOX-1 gene was …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease

A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
… -density lipoprotein (LDL) receptor-1 (LOX-1), a scavenger receptor that … In addition to its
expression in endothelial cells, LOX-1 is … , further implicating this receptor in multiple aspects of …

Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases

A Hofmann, C Brunssen, H Morawietz - Vascular pharmacology, 2018 - Elsevier
… of LOX-1 research, including novel insights into the receptor structure and function and newly
discovered ligands and describes in vivo findings on the contribution of LOX-1 to … LOX-1

Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers

V Lubrano, S Del Turco, G Nicolini, P Di Cecco… - Lipids, 2008 - Springer
lipoprotein receptor-1 (LOX-1) is increasingly linked to atherosclerotic plaque formation
and the soluble form of this receptor … levels of sLOX-1, oxidized-low-density lipoprotein (ox-LDL), …

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
lipoprotein LOX-1 ligand activity specifically. We have evaluated the level of the lipoprotein
LOX-1 … The level of the lipoprotein LOX-1 ligand was significantly increased in the plasma of …

Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells

A Pirillo, A Reduzzi, N Ferri, H Kuhn, A Corsini… - Atherosclerosis, 2011 - Elsevier
… overexpressed LOX-1 in an endothelial cell line and showed that 15LO-LDL were a ligand
for LOX-1, and that the interaction LOX-1/15LO-LDL upregulated ICAM-1 surface expression. …

[PDF][PDF] Oxidized low-density lipoprotein receptor, LOX-1, on the endothelial cell-the receptor structure and functions of LOX-1 in atherogenesis

S Tate - J Biol Macromol, 2007 - jsb.gr.jp
receptors on the macrophages, where various types of OxLDL receptors exist, LOX-1 is the
single class of OxLDL receptor … of the human oxidized low density lipoprotein receptor lox-1. …