Lipoteichoic acid synthesis and function in gram-positive bacteria

MG Percy, A Gründling - Annual review of microbiology, 2014 - annualreviews.org
… -positive bacteria: wall teichoic acid (WTA) and lipoteichoic acid (LTA). WTA synthesis has
recently been reviewed (17), and here we focus only on LTA synthesis. LTA is now defined as …

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS

D Lu, ME Wörmann, X Zhang… - Proceedings of the …, 2009 - National Acad Sciences
… The bacterial-specific peptidoglycan structure and its synthesis enzymes are a common
target for antibiotics. Lipoteichoic acid (LTA) is another abundant surface polymer present in the …

Defects in d-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid Sensitivity

DA Boyd, DG Cvitkovitch, AS Bleiweis… - Journal of …, 2000 - Am Soc Microbiol
… ) involved in the synthesis ofd-alanyl-lipoteichoic acid. Inactivation of thedltC gene, encoding
the d-alanyl carrier protein (Dcp), resulted in the generation of the acid-sensitive mutant, …

Synthesis of the first fully active lipoteichoic acid

A Stadelmaier, S Morath, T Hartung… - Angewandte Chemie …, 2003 - Wiley Online Library
… Owing to the sensitivity of lipoteichoic acids (LTAs) to hydrolysis their biological activity
could not be ascertained thus far. The chemical synthesis of LTA of Staphylococcus aureus 1, …

Chemical synthesis of bacterial lipoteichoic acids: an insight on its biological significance

RR Schmidt, CM Pedersen, Y Qiao… - Organic & biomolecular …, 2011 - pubs.rsc.org
… accepted hypothesis has been raised in that the lipoteichoic acids (LTAs) serve as pathogen-…
Hence, these LTAs have been synthesized in our group and biologically evaluated with …

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

SG Richter, D Elli, HK Kim… - Proceedings of the …, 2013 - National Acad Sciences
Lipoteichoic acid (LTA), a cell wall polymer of Gram-positive bacteria, consists of 1,3-…
phosphatidylglycerol binding to LtaS and inhibited LTA synthesis in S. aureus and in Escherichia …

Two‐enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes

AJ Webb, M Karatsa‐Dodgson… - Molecular …, 2009 - Wiley Online Library
Lipoteichoic acid (LTA) is an important cell wall polymer in Gram‐positive bacteria and often
consists a polyglycerolphosphate backbone chain that is linked to the membrane by a …

Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes

ME Wörmann, RM Corrigan, PJ Simpson… - Molecular …, 2011 - Wiley Online Library
acids are present, wall teichoic acid (WTA), which is covalently linked to peptidoglycan
and lipoteichoic acid (… subtilis synthesize this type of LTA consisting of an unbranched 1,3-linked …

Lipoteichoic acids and lipoglycans

W Fischer - New comprehensive biochemistry, 1994 - Elsevier
… large amounts of diacylglycerol are formed during lipoteichoic acid synthesis. For S. aureus,
… lipids) turns over three times for lipoteichoic acid synthesis, and the diacylglycerol formed …

Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system

I Campeotto, MG Percy, JT MacDonald… - Journal of Biological …, 2014 - ASBMB
Lipoteichoic acid (LTA) is an important cell wall component required for proper cell growth in
many Gram-positive bacteria. In Listeria monocytogenes, two enzymes are required for the …