Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts …

KLJ Desmet, WFA Marei, C Richard… - Human …, 2020 - academic.oup.com
… understanding of how the exposure of the oocyte to (pathophysiologically relevant) lipotoxic
conditions affected subsequent embryo development, we studied elongation, embryonic …

Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells

WFA Marei, G Van Raemdonck, G Baggerman… - Scientific reports, 2019 - nature.com
… cells, they remain largely unexplored in oocytes, which have distinct organelle structure and
… bovine oocytes and cumulus cells (CCs) after in vitro maturation under lipotoxic conditions; …

Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals

JPM Alves, M Bertolini, LR Bertolini… - Animal …, 2018 - animal-reproduction.org
oocyte in vitro maturation medium has been shown to slow the progression of meiosis,
hampering oocyte maturation … under in vivo or in vitro conditions, alters the expression pattern of …

The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity

F Lolicato, JF Brouwers, CHA de Lest… - Biology of …, 2015 - academic.oup.com
… -oocyte communication impairs bovine oocyte maturation … glucosylceramides under
lipotoxic-inducing conditions in COCs … oocyte maturation, and aberrations of the bidirectional …

Lipid metabolic process involved in oocyte maturation during folliculogenesis

T Liu, J Qu, M Tian, R Yang, X Song, R Li… - Frontiers in Cell and …, 2022 - frontiersin.org
… (PCOS) and induces lipotoxicity in oocytes, including the … Oocyte in vitro maturation
conditions are controlled by the simulation of the microenvironment to regulate oocyte maturation. …

Role of lipid metabolism and signaling in mammalian oocyte maturation, quality, and acquisition of competence

R Khan, X Jiang, U Hameed, Q Shi - Frontiers in cell and …, 2021 - frontiersin.org
… poor or rich metabolic conditions such as imbalance … oocyte maturation, growth and oocyte
competence acquisition. To understand the role of lipids in controlling the oocyte development

High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates

LLY Wu, KR Dunning, X Yang, DL Russell… - …, 2010 - academic.oup.com
… Further, ER stress and lipotoxicity have been demonstrated in liver and brain from both diet-…
lipotoxicity in other cells, we hypothesized that obesity results in the activation of lipotoxicity

[PDF][PDF] … cells protect the bovine oocyte against lipotoxicity by converting saturated into unsaturated fatty acids using stearoyl-CoA-desaturase during in vitro maturation

H Aardema, HTA Van Tol… - Anim …, 2016 - host-article-assets.s3.amazonaws …
… We assessed meiotic and cytoplasmic oocyte maturation, in … In our conditions, combination
of 50 ng/mL EGF, 100 ng/mL … pig oocytes since it offers superior results of oocyte maturation

[HTML][HTML] Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes

X Yang, LL Wu, LR Chura, X Liang, M Lane… - Fertility and sterility, 2012 - Elsevier
… with in vivo maturation conditions. … conditions, indicating that exposure to high levels of
lipids in follicle fluid is indeed inducing endoplasmic reticulum stress and potentially lipotoxicity

Alpha-linolenic acid protects the developmental capacity of bovine cumulus–oocyte complexes matured under lipotoxic conditions in vitro

WFA Marei, J De Bie, O Mohey-Elsaeed… - Biology of …, 2017 - academic.oup.com
… (ALA) during in vitro oocyte maturation (IVM) in the presence of PSO on subsequent embryo
… supplementation protected oocyte developmental capacity under lipotoxic conditions mainly …