… adipocyte lipid droplet, oxidative stress and fat remodeling. … triglyceride synthesis towards
the lipid droplet (1-acylglycerol-… Decreased triglyceride storage leads to adipocyte lipotoxicity…

… This high-lipid subpopulation accumulates more LDs and more … of lipotoxicity to the population
without impairing overall lipid homeostasis, since high-lipid cells can supply stored lipids …

… Failure of packaging of excess lipid into lipid droplets causes chronic elevation of circulating
… Lipid excess packaging into lipid droplets can be seen as an adaptive response to fulfilling …

… Our findings establish LD biogenesis as a general cellular response to periods of high
autophagic flux that provide a lipid buffering system to mitigate lipotoxic cellular damage. …

… Strikingly, the compensatory mechanisms activated in response to the high-fat diet–induced …
Furthermore, these lipotoxicity-induced changes were ameliorated by either elevating LD …

… It was shown that palmitate and oleate FAs elicit different cellular responses and contributions
to lipotoxicity. Unsaturated FAs like oleate are readily packaged into LDs and thus thought …

… is part of the adaptive response to fasting to alleviate lipid-induced insulin resistance and
to maintain mitochondrial function. Most of our knowledge on the response of PLIN5 to fasting …

… lipid storage. Furthermore, evidence shows that exercise training elevates markers of lipid
droplet … improved lipid turnover and a reduction in the accumulation of lipotoxic intermediates …

… of lipids and their intermediate products causes metabolic abnormalities and cell death, called
lipotoxicity… and defects in UPR signaling to lipotoxicity in peripheral tissues, understanding …

… ), we found that adding palmitoleate (C16:1n7) with palmitate suppressed cellular toxicity,
mitigated ER stress, increased the amount of TG in cellular lipid droplets, and suppressed …