Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity
C Vigouroux, M Caron-Debarle, C Le Dour… - The international journal …, 2011 - Elsevier
… adipocyte lipid droplet, oxidative stress and fat remodeling. … triglyceride synthesis towards
the lipid droplet (1-acylglycerol-… Decreased triglyceride storage leads to adipocyte lipotoxicity…
the lipid droplet (1-acylglycerol-… Decreased triglyceride storage leads to adipocyte lipotoxicity…
[HTML][HTML] Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity
… This high-lipid subpopulation accumulates more LDs and more … of lipotoxicity to the population
without impairing overall lipid homeostasis, since high-lipid cells can supply stored lipids …
without impairing overall lipid homeostasis, since high-lipid cells can supply stored lipids …
What is lipotoxicity?
AB Engin - Obesity and lipotoxicity, 2017 - Springer
… Failure of packaging of excess lipid into lipid droplets causes chronic elevation of circulating
… Lipid excess packaging into lipid droplets can be seen as an adaptive response to fulfilling …
… Lipid excess packaging into lipid droplets can be seen as an adaptive response to fulfilling …
Lipid droplets and lipotoxicity during autophagy
TB Nguyen, JA Olzmann - Autophagy, 2017 - Taylor & Francis
… Our findings establish LD biogenesis as a general cellular response to periods of high
autophagic flux that provide a lipid buffering system to mitigate lipotoxic cellular damage. …
autophagic flux that provide a lipid buffering system to mitigate lipotoxic cellular damage. …
Lipid droplets protect human β-cells from lipotoxicity-induced stress and cell identity changes
X Tong, R Stein - Diabetes, 2021 - Am Diabetes Assoc
… Strikingly, the compensatory mechanisms activated in response to the high-fat diet–induced …
Furthermore, these lipotoxicity-induced changes were ameliorated by either elevating LD …
Furthermore, these lipotoxicity-induced changes were ameliorated by either elevating LD …
Lipid droplets and fatty acid‐induced lipotoxicity: in a nutshell
… It was shown that palmitate and oleate FAs elicit different cellular responses and contributions
to lipotoxicity. Unsaturated FAs like oleate are readily packaged into LDs and thus thought …
to lipotoxicity. Unsaturated FAs like oleate are readily packaged into LDs and thus thought …
[HTML][HTML] Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans
… is part of the adaptive response to fasting to alleviate lipid-induced insulin resistance and
to maintain mitochondrial function. Most of our knowledge on the response of PLIN5 to fasting …
to maintain mitochondrial function. Most of our knowledge on the response of PLIN5 to fasting …
Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality
E Zacharewicz, MKC Hesselink… - Journal of Internal …, 2018 - Wiley Online Library
… lipid storage. Furthermore, evidence shows that exercise training elevates markers of lipid
droplet … improved lipid turnover and a reduction in the accumulation of lipotoxic intermediates …
droplet … improved lipid turnover and a reduction in the accumulation of lipotoxic intermediates …
[HTML][HTML] The role of ER stress in lipid metabolism and lipotoxicity
J Han, RJ Kaufman - Journal of lipid research, 2016 - ASBMB
… of lipids and their intermediate products causes metabolic abnormalities and cell death, called
lipotoxicity… and defects in UPR signaling to lipotoxicity in peripheral tissues, understanding …
lipotoxicity… and defects in UPR signaling to lipotoxicity in peripheral tissues, understanding …
[HTML][HTML] Probing the global cellular responses to lipotoxicity caused by saturated fatty acids
M Piccolis, LM Bond, M Kampmann, P Pulimeno… - Molecular cell, 2019 - cell.com
… ), we found that adding palmitoleate (C16:1n7) with palmitate suppressed cellular toxicity,
mitigated ER stress, increased the amount of TG in cellular lipid droplets, and suppressed …
mitigated ER stress, increased the amount of TG in cellular lipid droplets, and suppressed …
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