Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights

MB Gonzalez, RL Robker, RD Rose - Biology of reproduction, 2022 - academic.oup.com
… be mainly caused by lipotoxicity responses that promote ER … in ovarian follicular cells
which critically support the oocyte. … function, lipotoxicity in the cumulus oocyte complex is …

[PDF][PDF] Comparative expression profiles of genes related to cellular stress and development in oocyte of goats fed with distinct concentrations of lipids.

JPM Alves, CCL Fernandes, CR Lazzaroto, LH Aguiar… - 2015 - ufrgs.br
… in goats, the gene response of oocytes according to a defined … the quality of the oocytes,
cumulusoocyte complex (COC) and … to lipotoxicity mechanism and cellular stress in oocytes and …

Melatonin modulates lipid metabolism in porcine cumulus–oocyte complex via its receptors

T Zhu, S Guan, D Lv, M Zhao, L Yan, L Shi… - Frontiers in cell and …, 2021 - frontiersin.org
… The cumulus–oocyte complexes (COCs) were rinsed twice in HEPES-buffered Tyrode’s
Lactate (TL-HEPES) medium and then three times in maturation medium without hormones. The …

[引用][C] 1 CUMULUS CELLS PROTECT OOCYTES AGAINST POTENTIAL LIPOTOXICITY FROM ELEVATED FREE FATTY ACID CONCENTRATIONS IN FOLLICULAR …

SINAB CATTLE - Reproduction, Fertility and Development, 2013 - CSIRO Publishing
… can induce lipotoxicity in cumulus–oocyte-complexes in vitro, … Elevated HIF2A was likely in
response to oxidative stress … with oxidative stress were altered in response to the high oxygen …

Lipid metabolic process involved in oocyte maturation during folliculogenesis

T Liu, J Qu, M Tian, R Yang, X Song, R Li… - Frontiers in Cell and …, 2022 - frontiersin.org
… biological system of complex components including oocytes, granulosa cells, … in oocytes
of women with obesity or polycystic ovary syndrome (PCOS) and induces lipotoxicity in oocytes, …

Fatty acid induced lipolysis influences embryo development, gene expression and lipid droplet formation in the porcine cumulus cells

P Pawlak, N Malyszka, I Szczerbal… - Biology of …, 2020 - academic.oup.com
… in porcine cumulus–oocyte complexes and … oocytes from lipotoxicity under the excess of FA
in culture media. Results of the present experiment revealed a distinct response of the oocyte

Cumulus‐oocyte complexes from sows show differences in lipid metabolism compared to cumulus‐oocyte complexes from prepubertal gilts during in vitro maturation

TCF Silva, MAN Dode, TF Braga… - Molecular …, 2023 - Wiley Online Library
oocyte complexes were collected from sows and prepubertal gilts. In total, eight groups were
analyzed: immature oocytesReactions were performed at 25C for 5 min and 42C for 60 min…

Response of bovine cumulus–oocytes complexes to energy pathway inhibition during in vitro maturation

P Lipinska, E Sell-Kubiak, P Pawlak, ZE Madeja… - Genes, 2021 - mdpi.com
oocyte during IVM since only glucose inhibition decreased embryo culture efficiency. The
most noteworthy differences in the reaction … On the contrary, etomoxir treatment of the oocytes

Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role?

N Turner, RL Robker - Molecular human reproduction, 2015 - academic.oup.com
… and is the site of the electron transport chain complexes. Within the matrix there are a large
… space through complex I, III and IV. The electrons are transferred to oxygen at complex IV to …

Impact of short-term high-fat feeding on lipid droplet content in mouse oocytes

R Aizawa, M Ibayashi, T Hatakeyama… - … of Reproduction and …, 2021 - jstage.jst.go.jp
… may reveal the unknown mechanisms involved in oocyte competence. In … oocytes. In
preliminary studies, to investigate if short-term high-fat feeding affects oocyte maturation in response