… metabolite matrine (MT) after iv administration of OMT in human. Therefore a specific and
sensitive liquid chromatography … study of OMT and its metabolite MT in human plasma after iv …

… The liquid chromatography separation system comprised LC-10AD VP (pump), DGU-14AM
(… that matrine as the active metabolite of oxymatrine had a t 1/2 of 9.4 h in humans [13]. …

… two sites, sorting out the role of skin in transdermal delivery and dermal metabolism.
Oxymatrine (OMT) and matrine (MT) are the major quinolizidine alkaloids from the root of Sophora …

… (OMT) and its metabolite matrine (MT) in beagle dog plasma using a liquid–liquid extraction
procedure followed by liquid chromatography–electrospray ionization mass spectrometric (…

… liquid chromatography mass spectrometry (LC-MS) method of OMT and its active metabolite
MT … We used aminopyrine as an internal standard and relatively fast liquid-liquid extraction …

… Rat liver microsome studies showed that CYP and UGTs were not involved in matrine
metabolism. In conclusion, a sensitive and reliable method capable of measuring …

… Recently, much attention has been paid to the absorption and metabolism of matrine and
oxymatrine, and a few papers dealing with their pharmacokinetics and pharmacodynamics …

… Thirdly, the in vivo metabolites of MASM were also estimated in our present study. … metabolites,
we initially postulated their potential structures by considering the established metabolic …

… into matrine by human intestinal bacteria metabolism in vitro [5]. … rats were analysed by
liquid chromatography-tandem mass … I metabolites were identified and the main metabolite was …

… liquid chromatography tandem mass spectrometric method (HPLC-MS) has been developed
and validated for the simultaneous determination of matrine (… by liquid–liquid extraction with …