Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells

T Yamashita, S Kaneko - Journal of gastroenterology, 2014 - Springer
… We further explored the tumorigenic capacity of sorted cells isolated from 15 primary
HCCs and 7 liver cancer cell lines [36]. Although the number of samples analyzed was small, …

Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells

H Liu, W Zhang, Y Jia, Q Yu, GE Grau, L Peng… - Cell death & …, 2013 - nature.com
… aspect of the cancer stem cell hypothesis, which claims that single-cell-cloned liver CSCs
can self-… Importantly, we now formally confirm that the single-cell-cloned liver CSCs have the …

[PDF][PDF] SIRT1‐mediated transcriptional regulation of SOX2 is important for self‐renewal of liver cancer stem cells

L Liu, C Liu, Q Zhang, J Shen, H Zhang, J Shan… - …, 2016 - Wiley Online Library
… -renewal of embryonic stem cells and hematopoietic stem cells, especially under conditions
cancer and stem cell biology, we hypothesized that SIRT1 may participate regulation of liver

Tumor-initiating stem cells in liver cancer

SY Yi, KJ Nan - Cancer biology & therapy, 2008 - Taylor & Francis
… that cancer is a stem cell disorder. There are major implications for the way we study,
diagnose and treat liver cancer if the same populations of liver cancer stem/progenitor cells are …

YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation

C Zhang, S Huang, H Zhuang, S Ruan, Z Zhou… - Oncogene, 2020 - nature.com
… To determine the effect of YTHDF2 on liver cancer in vivo, we performed an orthotopic
transplantation experiment by injecting male BALB/c nude mice with 1 × 10 6 NTC, shYTH#1 or …

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

P Zhu, Y Wang, Y Du, L He, G Huang, G Zhang… - Nature …, 2015 - nature.com
Liver cancer stem cells (CSCs) harbour self-renewal and … However, the molecular
mechanisms to sustain liver CSCs … and liver CSCs. C8orf4 attenuates the self-renewal capacity of …

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

X Jiang, L Xing, Y Chen, R Qin, S Song, Y Lu… - … Therapy-Nucleic Acids, 2021 - cell.com
… HULC and Cbf5 in human liver cancer stem cell. Strikingly, … liver cancer stem cells. In
summary, these observations provide important basic information for finding effective liver cancer

ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells

P Zhu, Y Wang, L He, G Huang, Y Du… - The Journal of …, 2015 - Am Soc Clin Investig
Liver cancer stem cells (CSCs) have been identified and shown to have self-renewal and …
profiles of liver CSCs and non-CSCs from hepatocellular carcinoma (HCC) cells lines and …

Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice

CB Rountree, W Ding, L He, B Stiles - Stem cells, 2009 - academic.oup.com
… potential expansion of a malignant stem cell population during disease … liver-specific PTEN
loss, we intend to define a population of liver cancer stem cells isolated during chronic liver

lncARSR promotes liver cancer stem cells expansion via STAT3 pathway

C Yang, W Cai, Z Dong, J Guo, Y Zhao, C Sui, J Yang - Gene, 2019 - Elsevier
Liver cancer stem cells (CSCs) have important functions in … of renal cancer stem cells, but
its role in liver cancer stem cells (… in EpCAM or CD133–positive liver CSCs as well as in CSC-…