Cancer stem cells and hepatocellular carcinoma

Z Yao, L Mishra - Cancer biology & therapy, 2009 - Taylor & Francis
… How the Wnt pathway promotes stem cell renewal and is involved in liver cancer stem cells,
… to sustain stem cell proliferation, and is essential for the differentiation of specific cell types. …

Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways

R Galuppo, E Maynard, M Shah, MF Daily… - Anticancer …, 2014 - ar.iiarjournals.org
… to address Huh7 and liver cancer stem cell (LCSC) inhibition … This drug was shown to inhibit
growth of hepatoblastoma cell … the sensitivity of HCC and liver cancer stem cell (LCSC) lines …

[HTML][HTML] MiR-155 targets TP53INP1 to regulate liver cancer stem cell acquisition and self-renewal

F Liu, X Kong, L Lv, J Gao - FEBS letters, 2015 - Elsevier
… to enrich for liver cancer stem cells. The expression of liver cancer stem cell markers, such
as … increased in spheres compared with parental cells. These results indicated that spheres …

microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb

J Zhang, N Luo, Y Luo, Z Peng… - … journal of oncology, 2012 - spandidos-publications.com
… tigate the potential role of miR-150 in liver cancer stem cells, we examined whether
overexpression of miR-150 could inhibit the CD133+ cells and their self-renewal potential. Fig. 7A …

Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications

TKW Lee, XY Guan, S Ma - Nature reviews Gastroenterology & …, 2022 - nature.com
… -sorting and xenotransplantation techniques identified various liver cancer stem cell (CSC)
markers. These studies also laid important groundwork for current research in this field. …

PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor

F Liu, X Wu, Y Qian, X Jiang, Y Wang, J Gao - Cell Death & Disease, 2020 - nature.com
… The existence of cancer stem cells (CSCs) accounts for … Although the elimination of cancer
stem cells is crucial for cancer … HCC tissues and liver CSCs. Upregulated PIK3C3 facilitated …

[HTML][HTML] EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1

DJ Park, PS Sung, JH Kim, GW Lee… - … of cancer, 2020 - ncbi.nlm.nih.gov
… expression of NK cell ligands according to other cancer stem cell markers such as CD13,
CD133, and ALDH levels in Huh-7 cells (online supplementary figure 3), as well as in HepG2 …

HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway

M Zhu, W Li, Y Lu, X Dong, B Lin… - … Journal of Cancer, 2017 - Wiley Online Library
… The effects of HBx on the ability of normal human liver cell lines, L-02 and CHL to generate
cancer stem cells. (a) and (b), L-02 cells (a) and CHL cells (b) were transfected with MCV-…

Combinatorial photochemotherapy on liver cancer stem cells with organoplatinum (ii) metallacage-based nanoparticles

B Yang, H Liu, H Yang, W Chen, J Wu… - Journal of Materials …, 2019 - pubs.rsc.org
… Among them, liver cancer is the fourth most frequent cause of cancer … of liver cancer stem
cells (CSCs). CSCs, also called tumor initiating stem-like cells, are a subset of cancer cells with …

iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

R Wang, Y Li, A Tsung, H Huang… - Proceedings of the …, 2018 - National Acad Sciences
… Notch signaling in cancer stem cells promotes cancer progression and requires Notch cleavage
by … in liver cancer stem cells (LCSCs), leading to a more aggressive cancer phenotype. …