Alcoholic liver disease: mechanisms of injury and targeted treatment

A Louvet, P Mathurin - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
… of liver disease, as well as potential therapeutic strategies targeting these pathways. … injury.
Hepatocytes proliferate in the absence of chronic liver disease, but in ALD this mechanism is …

Cellular and molecular mechanisms of liver injury

H Malhi, GJ Gores - Gastroenterology, 2008 - Elsevier
… of the liver in chronic liver diseases. Endothelial cell apoptosis occurs in ischemia-reperfusion
injury. … in the understanding of the injury mechanisms leading to end-stage liver disease. …

Mechanisms of liver injury: an overview

H Higuchi, GJ Gores - Current molecular medicine, 2003 - ingentaconnect.com
… role of apoptosis in liver diseases, we are now entering an … liver disease, and the risk
factors for alcoholic liver disease … to alcoholism and alcoholic liver disease. In addition, alcohol …

Pathogenesis of alcoholic liver disease: newer mechanisms of injury

DW Crabb - The Keio journal of medicine, 1999 - jstage.jst.go.jp
… of women to alcoholic liver disease. Activation of HSC underlies liver fibrosis and cirrhosis
… These advances suggest a number of new approaches as therapy for alco holic liver injury. (…

Mechanisms of liver cell injury

N Kaplowitz - Journal of hepatology, 2000 - Elsevier
… The extensive knowledge gained in recent years about the mechanisms of cell death will …
of liver diseases. Important targets include death receptors, death signaling mechanisms, the …

Mechanisms of alcoholic liver injury

SW French - Canadian Journal of Gastroenterology and …, 2000 - Wiley Online Library
There have been numerous recent advances in the understanding of the mechanisms of
alcoholic liver disease pathogenesis. Endotoxin‐induced Kupffer cell activation plays a role in …

Mechanisms of liver injury relevant to pediatric hepatology

MS Tanner - Critical reviews in clinical laboratory sciences, 2002 - Taylor & Francis
… : Hepatocyte injury and necrosis from many causes may result in pediatric liver disease. …
review describes immune mechanisms of liver injury, as seen in autoimmune hepatitis, hepatitis …

Reactive oxygen and mechanisms of inflammatory liver injury

H Jaeschke - Journal of gastroenterology and hepatology, 2000 - Wiley Online Library
… in a number of liver diseases, the detailed mechanisms of reactive … may play, elucidating
injury mechanisms will be critical for … of the important mechanisms of ROS-induced injury during …

Biochemical and cellular mechanisms of toxic liver injury

N Kaplowitz - Seminars in liver disease, 2002 - thieme-connect.com
The pathogenesis of drug-or toxin-induced liver injury usually involves the participation of
toxic metabolites that either elicit an immune response or directly affect the biochemistry of the …

[HTML][HTML] Characteristics and mechanism of liver injury in 2019 coronavirus disease

J Li, JG Fan - Journal of clinical and translational hepatology, 2020 - ncbi.nlm.nih.gov
… -induced liver injury should first be confirmed or ruled out. In addition, given the high burden
of chronic liver disease in China, nonalcoholic fatty liver disease, chronic hepatitis B, and …