Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes

LE Nagy, WX Ding, G Cresci, P Saikia, VH Shah - Gastroenterology, 2016 - Elsevier
… markers of ethanol-induced liver injury. We review the mechanisms by which alcohol injures
… We also discuss how recent insights into the pathogenesis of ALD will affect the treatment …

[HTML][HTML] Pathogenesis and pathways: nonalcoholic fatty liver disease & alcoholic liver disease

KE Robinson, VH Shah - Translational Gastroenterology and …, 2020 - ncbi.nlm.nih.gov
… Development of severe liver disease is highly … to NAFLD, but by contrast, insulin resistance
is widely believed to be the main driver of nonalcoholic hepatic steatosis. The mechanism

Nonalcoholic fatty liver disease: pathology and pathogenesis

DG Tiniakos, MB Vos, EM Brunt - … : Mechanisms of Disease, 2010 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is recognized as the leading cause of chronic liver
disease in adults and children. NAFLD encompasses a spectrum of liver injuries ranging …

Pathophysiology and mechanisms of nonalcoholic fatty liver disease

JT Haas, S Francque, B Staels - Annual review of physiology, 2016 - annualreviews.org
… is considered a general model of liver fibrosis, its use is … to study mechanisms of fibrogenesis
in specific liver diseases such … that liver fibrosis may be reversible in several liver diseases, …

[HTML][HTML] Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

GÖ Elpek - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
… These findings have provided progressed the understanding of the pathogenesis of chronic
liver diseases and have presented opportunities for novel therapeutic approaches for the …

Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives

XD Yu, JW Wang - Biochemical Pharmacology, 2022 - Elsevier
… seems efficacious for the treatment of NAFLD. In this review, we provide an overview of the
pathogenic mechanisms of ceramides in NAFLD, discuss recent advances and challenges in …

Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

T Hardy, F Oakley, QM Anstee… - … : mechanisms of disease, 2016 - annualreviews.org
… The principal disadvantage of this model is its dissimilarity to the pathogenic mechanisms
operating in metabolic syndrome–related NAFLD in humans. In contrast, animals fed an MCD …

Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease

C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-term
alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

Mechanisms of disease progression in nonalcoholic fatty liver disease

J Jou, SS Choi, AM Diehl - Seminars in liver disease, 2008 - thieme-connect.com
NAFLD is the most common cause of chronic liver disease in many Western countries.[1] …
the understanding of the mechanisms that contribute to the progression of disease in NAFLD. …

Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis

S Spahis, E Delvin, JM Borys, E Levy - Antioxidants & redox …, 2017 - liebertpub.com
… in the understanding of NAFLD, essentially focusing on OxS as a major pathogenetic mechanism.
… have been associated to NAFLD and related complications, mechanisms of action and …