… liver conditions including hepatitis, alcoholic liver disease, acute liver failure, I/R injury, liver
… Much work has been done to further our understanding of the mechanisms of liver disease. …

… , and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα)
is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation …

… of human NAFLD. The importance of TNFin human and animal fatty liver diseases, both due
… Furthermore, neutralization of TNF- activity improves IR and fatty liver disease in animals. IL-…

… ) has emerged as a key factor in various aspects of liver disease, such as … of TNF-α and
other injuryrelated cytokines in liver diseases merits evaluation as a treatment of these diseases. …

… Animal models highlighting the role of TNF-α. Human data supporting a key role for TNF-α
in alcohol-related liver diseases are further substantiated by data from animal experiments (25…

… (NASH) with a concomitant elevation of plasma TNF-α. In this study, we analyzed the role
of TNF-α in the progression of nonalcoholic fatty liver disease (NAFLD). We established a …

… disease (NAFLD). We measured serum levels of TNF-α and leptin and computed NAFLD …
[NASH]) in 72 consecutive biopsy-proven NAFLD cases (training and validation sets, 36 cases …

… in circulating TNF-α between NAFL and NASH patients [48, 49]. … TNF-α was associated
with the severity of NAFLD: TNF-α was higher in patients with NAFL than in non-NAFLD controls …

… biology in liver diseases so far has been accumulated from alcoholic liver disease (ALD).
Acute … of interleukin-1 (IL-l), TNFa, and IL-6,1g~20~24~26-28~37 However, what is lacking are …

… fatty liver disease, which can range from fatty liver alone to … Tumor necrosis factor α (TNF-α)
may induce insulin resistance, … TNF-α polymorphisms, and (3) the relationship among TNF-…