… role of genetic testing in monogenic liver diseases, compile … new concepts in the genetics
of liver diseases in general. We … identifying genetic associations with complex liver diseases, …

… from genetic association studies linking PNPLA3 to more severe liver disease phenotypes
… Finally, we discuss the contribution of this gene to the risk of liver diseases and its potential …

… In the ‘pre-GWAS’ era, genetic studies of autoimmune liver disease consisted of candidate
gene association studies investigating specific HLA alleles (HLA association studies) or a …

… range of disorders affecting the liver. In this review we summarize liver diseases with clinical
manifestation in adulthood in which genetic variants contribute to disease development or …

… -6 gene and affects IL-6 production. However, the data in the literature on the genetic
association between the -174 G/C polymorphism and some specific liver diseases characterized by …

… (NAFLD); however, very few predisposing genes have been identified. We aimed to (1)
identify novel genetic associations with NAFLD by performing a genome-wide association study (…

Background Some observational studies found that dyslipidaemia is a risk factor for non-alcoholic
fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk. However, …

… These candidate genes have been selected largely based upon the “two-hit hypothesis” of
… also be informative in gene selection. Thus far, candidate gene association studies have had …

… Non-alcoholic fatty liver disease has an increasing … genetic association studies that
investigate possible genetic influences that confer susceptibility to non-alcoholic fatty liver disease …

… This clearly poses particular problems for studies looking for genes determining susceptibility
to advanced liver disease. Variations on the TDT using siblings of affected individuals (…