Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats

SW Luckey, DR Petersen - Experimental and molecular pathology, 2001 - Elsevier
… Kupffer cells are involved in the pathogenesis of chemically mediated liver injury through …
tetrachloride (CCl 4 )-mediated liver injury and fibrosis. Rats were administered 1 ml/kg of CCl …

Liver fibrosis: mechanisms of immune-mediated liver injury

R Xu, Z Zhang, FS Wang - Cellular & molecular immunology, 2012 - nature.com
… Expression of both TIMP-1 and TIMP-2 is increased in human fibrotic liver and in a rat
model of liver fibrosis. Moreover, the degree of TIMP-1 expression correlates with the extent of …

Protective effects of total flavonoids of Bidens pilosa L.(TFB) on animal liver injury and liver fibrosis

LP Yuan, FH Chen, L Ling, PF Dou, H Bo… - Journal of …, 2008 - Elsevier
… in liver fibrosis of rats. The histopathological analysis suggested that TFB reduced the degree
of liver injury in mice and severity of liver fibrosis in rats. … effect on animal liver injury, which …

Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated Rats

S Clichici, D Olteanu, AL Nagy, A Oros… - Journal of medicinal …, 2015 - liebertpub.com
… of almost all chronic liver diseases, is the consequence of hepatocyte injury that leads to the
… model of liver fibrosis with a focus on the early stages of liver injury. Fifty Wistar rats were …

[HTML][HTML] Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury

B Liang, XL Guo, J Jin, YC Ma… - World Journal of …, 2015 - ncbi.nlm.nih.gov
fibrosis in carbon tetrachloride (CCl 4)-induced liver injury and its contributing factors.
METHODS: Liver fibrosis … Pathological changes in the liver of rats were examined by hematoxylin-…

Ethanol-induced liver fibrosis in rats fed high fat diet

H Tsukamoto, SJ Towner, LM Clofalo, SW French - Hepatology, 1986 - journals.lww.com
… -induced liver injury were investigated. Seventeen pairs of male Wistar rats were implanted
… Light and electron microscopic examination of the liver revealed moderate to severe fatty …

Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury

AB Carvalho, LF Quintanilha, JV Dias, BD Paredes… - Stem …, 2008 - academic.oup.com
… We conclude that in this chronic liver injury model, cell therapy using mesenchymal
stromal cells from the bone marrow does not reduce fibrosis or improve liver function when …

Hepatic stimulator substance alleviates toxin-induced and immune-mediated liver injury and fibrosis in rats

X Yi, M Song, Y Yuan, X Zhang, W Chen, J Li… - Digestive diseases and …, 2012 - Springer
… 4 )-induced and porcine-serum-mediated hepatic injury and fibrosis. We hypothesize that
HSS might attenuate liver injury and fibrosis by suppressing oxidative stress, down-regulating …

[PDF][PDF] Apoptosis: the nexus of liver injury and fibrosis

A Canbay, S Friedman, GJ Gores - Hepatology, 2004 - Wiley Online Library
… for its antifibrotic potential in alcoholic liver injury.A related compound, dilinoleoylphosphatidylcholine,
prevents TGF-ßJmediated collagen accumulation in cultured rat HSCs through an …

Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury

P Sancho–Bru, R Bataller, G Fernandez–Varo… - Gastroenterology, 2007 - Elsevier
livers from normal rats and in rats with chronic liver injury. B1 and B2 receptors were expressed
in normal rat livers and they were over expressed in CCl 4 -treated rats (… the fibrotic bands…