Inflammasome activation and function in liver disease

G Szabo, J Petrasek - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
liver injury and disease progression. Specifically, we focus on the triggers of inflammasome
activation … infection, ischaemia–reperfusion injury and paracetamol-induced liver injury. The …

The role of the NLRP3 inflammasome and programmed cell death in acute liver injury

C Yu, P Chen, L Miao, G Di - International Journal of Molecular Sciences, 2023 - mdpi.com
… regulate NLRP3 inflammasome activation. This indicates that NLRP3 inflammasome activation
is … In this review, we summarize the role of NLRP3 inflammasome activation and PCD in …

Role of the inflammasome in liver disease

M de Carvalho Ribeiro, G Szabo - Annual Review of Pathology …, 2022 - annualreviews.org
… TG accumulation in hepatocytes and induces liver injury through TNF-α activation. (➇) In …
Our group demonstrated that signals for NLRP3 inflammasome activation in ALD involve a …

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury

A Shi, H Shi, Y Wang, X Liu, Y Cheng, H Li… - International …, 2018 - Elsevier
… NLRP3 inflammasome activation. Although the protective effects of CGA on liver injury have
… of CGA could inhibit NLRP3 inflammasome activation in liver probably through modulating …

The inflammasome in liver injury and non-alcoholic fatty liver disease

WZ Mehal - Digestive diseases, 2014 - karger.com
… The model of inflammasome activation as outlined above … observe with acute inflammasome
activation. Many important … The above model of inflammasome activation cannot explain …

Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation

L Shi, S Zhang, Z Huang, F Hu, T Zhang, M Wei… - Free Radical Biology …, 2020 - Elsevier
… APAP-induced liver injury in wild-… liver regeneration after APAP-induced acute liver injury
in mice via inducing Nrf2 accumulation in cytoplasm that led to NLRP3 inflammasome activation

Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice

Z Wang, G Xu, X Zhan, Y Liu, Y Gao, N Chen… - Archives of …, 2019 - Springer
liver injury through promoting specific stimuli-induced NLRP3 inflammasome activation. …
Therefore, the effect of CBZ on NLRP3 inflammasome activation and liver injury as well as the …

Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation

D Wang, M Zhang, T Wang, M Cai, F Qian, Y Sun… - Food & function, 2019 - pubs.rsc.org
… and NLRP3 inflammasome activation. GTPs exert protective effects against inflammatory
liver injury by regulating NF-κB signaling and the NLRP3 inflammasome activation. Our …

Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway

Y Zhang, X Qu, H Gao, J Zhai, L Tao, J Sun… - International …, 2020 - Elsevier
… to improve liver injury by attenuating NLRP3 inflammasome activation [27]. … liver injury. In
this paper, consistent with previous reports, we found that NLRP3 inflammasome activation was …

Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation

S Shan, Z Shen, C Zhang, R Kou, K Xie… - Biochemical …, 2019 - Elsevier
… (APAP)-induced acute liver injury. Mitophagy is a type of … establish a model of acute liver
injury via intraperitoneal (ip) … mitophagy and NLRP3 inflammasome pathway were determined …