… livers … cholangiocyte organoids in liver ECM(LECM)-derived hydrogels is described. These
hydrogels support proliferation of cholangiocyte organoids and maintain the cholangiocyte-…

… junction marker, in hepatic organoids and primary cilia … cholangiocytes in organoids.(12)
Abundant bile acids were detected in organoid supernatant, indicating that the hepatic organoid …

… hepatocyte progenitors and cholangiocytes. … liver tissue incorporating a bile drainage system
ex vivo. HBTO enable us to reproduce the transport of hepatocyte metabolites in liver tissue…

… Cholangiocyte organoids have been established to study normal cholangiocyte biology and
… test organoid potential to form bile ducts and gallbladder tissue in vitro. Hepatobiliary cancer …

… cholangiocyte organoids in the context of cholangiopathies, which represent a key reason
for liver … Using single-cell RNA sequencing, we show that primary human cholangiocytes …

… in cholangiocytes covering different parts of the EHBD. In this study, 3D cholangiocyte
organoids … Initially, cholangiocyte organoids were initiated from liver biopsies, and described as …

… (Left) ICO culture 5 d after plating, demonstrating the emergence of an organoid from a
segment of liver tissue. (Right) Established ICO line (passage 20). Scale bars, 200 μm. …

… of organoids incubated with free fatty acids or without. We also compared gene expression
profiles between liver tissue … hepatocyte and cholangiocyte populations in organoids using …

… Human cholangiocyte organoids … organoids lack the branching morphology of intrahepatic
bile ducts (IHBDs). Here, we report establishing human branching cholangiocyte organoid (…

… organoid initiation and as a response to tissue damage We recently reported a liver organoid
… mouse 4 and human 13 liver ductal cells as self-renewing bi-potent organoids capable of …