… for the failure of drug candidates in the pre-clinical or … liver toxicity genomic biomarkers from
a liver toxicity biomarker study involving the paired compounds entacapone (“non-liver toxic …

… to detect novel and complementary candidate markers for liver injury. We generated an …
was the identification of candidate low invasive markers for liver damage. Some existing in …

… systems based on toxicity pathway markers. An examination of the current practices in
clinical pathology and the critical evaluation of some recently proposed biomarker candidates in …

… resources in regard to candidate TGx biomarkers for liver toxicity and overview their …
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver …

… This study was designed to evaluate the performance of a set of non-invasive candidate
markers for improved detection of drug-induced liver injury as compared to traditional …

… the selection of toxicity marker candidates from cell culture based toxicity test systems, we
created and evaluated 2-D gel based proteome databases of compound treated rat liver and …

… Out of the 31 candidate hepatotoxicity marker genes which were tested in this study, 11 (35%)
were found to be specific for liver toxicity—they were differentially expressed in the blood …

… or body fluids that can be used to distinguish drug candidates that have the potential to … In
this article, we present the results for the liver and plasma markers discovered across the same …

… are needed to better predict liver toxicity. The omics technologies … of the qualification of
biomarker candidates is also given. … of liver, kidney, and seminal vesicles and is a marker of acute …

… directly from injured tissue should yield markers specific for the injury that permit … the liver
is the principal organ of detoxification and is at risk of injury from both new drug candidates and …